A triterpenoid with diverse biological activities
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Ganoderol B

Item No. 34324

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
lanosta-7,9(11),24E-triene-3β,26-diol
CAS Number
104700-96-1
Synonyms
  • Ganodermadiol
  • (+)-Ganoderol B
Molecular Formula
C30H48O2
Formula Weight
440.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
C[C@]12C3=CC[C@](C(C)([C@H](CC4)O)C)([H])[C@@]4(C)C3=CC[C@@]1([C@]([C@@H](CC/C=C(C)/CO)C)([H])CC2)C
InChi Code
InChI=1S/C30H48O2/c1-20(19-31)9-8-10-21(2)22-13-17-30(7)24-11-12-25-27(3,4)26(32)15-16-28(25,5)23(24)14-18-29(22,30)6/h9,11,14,21-22,25-26,31-32H,8,10,12-13,15-19H2,1-7H3/b20-9+/t21-,22-,25+,26+,28-,29-,30+/m1/s1
InChi Key
AOXXVRDKZLRGTJ-AZIDVCJLSA-N
Origin
Fungus/Ganoderma lucidum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $90

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    5 mg

    $392

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    10 mg

    $653

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    Product Description

    Ganoderol B is a triterpenoid that has been found in G. lucidum and has diverse biological activities.1,2,3,4,5 It inhibits angiotensin-converting enzyme (ACE) and α-glucosidase (IC50s = 220 and 119.8 µM, respectively).1,2 Ganoderol B is cytotoxic to HGC-27 gastric, HeLa cervical, and A549 lung cancer cells (IC50s = 16.15, 12.64, and 9.77 µM, respectively).3 It prevents herpes simplex virus 1 (HSV-1) infection in Vero cells (EC50 = 68 µM).4 Ganoderol B (0.001 and 0.1 mg/kg) reduces testosterone-induced increases in ventral prostate weight in castrated rats.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Morigiwa, A., Kitabatake, K., Fujimoto, Y., et al. Angiotensin converting enzyme-inhibitory triterpenes from Ganoderma lucidum. Chem. Pharm. Bull. (Tokyo) 34(7), 3025-3028 (1986).

    2. Fatmawati, S., Shimizu, K., and Kondo, R. Ganoderol B: A potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum. Phytomedicine 18(12), 1053-1055 (2011).

    3. Su, H.-G., Zhou, Q.-M., Guo, L., et al. Lanostane triterpenoids from Ganoderma luteomarginatum and their cytotoxicity against four human cancer cell lines. Phytochemistry 156, 89-95 (2018).

    4. Mothana, R.A.A., Ali, N.A.A., Jansen, R., et al. Antiviral lanostanoid triterpenes from the fungus Ganoderma pfeifferi. Fitoterapia 74(1-2), 177-180 (2003).

    5. Liu, J., Shimizu, K., Konishi, F., et al. The anti-androgen effect of ganoderol B isolated from the fruiting body of Ganoderma lucidum. Bioorg. Med. Chem. 15(14), 4966-4972 (2007).