A triterpene with diverse biological activities
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Ganodermanontriol

Item No. 34325

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
24S,25R,26-trihydroxy-lanosta-7,9(11)-dien-3-one
CAS Number
106518-63-2
Molecular Formula
C30H48O4
Formula Weight
472.7
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
λmax
244, 253 nm
SMILES
C[C@@]12C3=CC[C@](C)([C@]([C@@H](CC[C@H](O)[C@@](O)(C)CO)C)([H])CC4)[C@]4(C)C3=CC[C@@]1([H])C(C)(C(CC2)=O)C
InChi Code
InChI=1S/C30H48O4/c1-19(8-11-25(33)30(7,34)18-31)20-12-16-29(6)22-9-10-23-26(2,3)24(32)14-15-27(23,4)21(22)13-17-28(20,29)5/h9,13,19-20,23,25,31,33-34H,8,10-12,14-18H2,1-7H3/t19-,20-,23+,25+,27-,28-,29+,30-/m1/s1
InChi Key
KASALCUNLBTNAA-LIPCCPSCSA-N
Origin
Fungus/Ganoderma lucidum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $248

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    5 mg

    $1,052

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    Product Description

    Ganodermanontriol is a triterpene that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It inhibits the activity of HIV-1 protease (IC50 = 70 µM), as well as reduces the activity of 5α-reductase by 32% when used at a concentration of 667 µM.1,2 Ganodermanontriol (25 and 50 µM) inhibits proliferation, colony formation, invasion, and migration of MDA-MB-231 human breast cancer cells.3 It reduces hepatocyte necrosis and increases in hepatic TNF-α and IL-6 levels in a mouse model of LPS/D-galactosamine-induced acute liver injury when administered at a dose of 5 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Min, B.-S., Nakamura, N., Miyashiro, H., et al. Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV-1 protease. Chem. Pharm. Bull. 46(10), 1607-1612 (1998).

    2. Liu, J., Kurashiki, K., Shimizu, K., et al. Structure–activity relationship for inhibition of 5α-reductase by triterpenoids isolated from Ganoderma lucidum. Bioorg. Med. Chem. 14(24), 8654-8660 (2006).

    3. Jiang, J., Jedinak, A., and Silva, D. Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. Biochem. Biophys. Res. Commun. 415(2), 325-329 (2011).

    4. Hu, Z., Du, R., Xiu, L., et al. Protective effect of triterpenes of Ganoderma lucidum on lipopolysaccharide-induced inflammatory responses and acute liver injury. Cytokine 127, 154917 (2020).