An Eg5 inhibitor
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ARQ 621

Item No. 34329

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-aminopropyl)-3-chloro-N-[(1R)-1-[7-chloro-3,4-dihydro-4-oxo-3-(phenylamino)-2-quinazolinyl]-3-butyn-1-yl]-2-fluoro-benzamide
CAS Number
1095253-39-6
Molecular Formula
C28H24Cl2FN5O2
Formula Weight
552.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
239 nm
SMILES
O=C(C1=C(C(Cl)=CC=C1)F)N(CCCN)[C@@H](C(N2NC3=CC=CC=C3)=NC4=CC(Cl)=CC=C4C2=O)CC#C
InChi Code
InChI=1S/C28H24Cl2FN5O2/c1-2-8-24(35(16-7-15-32)27(37)21-11-6-12-22(30)25(21)31)26-33-23-17-18(29)13-14-20(23)28(38)36(26)34-19-9-4-3-5-10-19/h1,3-6,9-14,17,24,34H,7-8,15-16,32H2/t24-/m1/s1
InChi Key
UPJSUQWHUVLLNW-XMMPIXPASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $40

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    5 mg

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    10 mg

    $257

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    25 mg

    $590

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    Cayman Chemical
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    Product Description

    ARQ 621 is an Eg5 inhibitor.1 It reduces tumor growth in a MIA PaCa-2 pancreatic cancer mouse xenograft model when administered at a dose of 6.25 mg/kg

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jeay, S., Ali, S., Chen, C.-R., et al. Discovery of a novel Eg5 kinesin inhibitor, ARQ 621, with potent antitumor activity while sparing bone marrow-derived cells. Cancer Res. 68(9 Suppl.), 656 (2008).