An inducer of Oct3/4 expression
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MDK35833

Item No. 34332

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(4-fluorophenyl)methoxy]-benzeneacetonitrile
CAS Number
1016535-83-3
Molecular Formula
C15H12FNO
Formula Weight
241.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/mlEthanol: 15 mg/ml
λmax
227 nm
SMILES
N#CCC1=CC=C(OCC2=CC=C(C=C2)F)C=C1
InChi Code
InChI=1S/C15H12FNO/c16-14-5-1-13(2-6-14)11-18-15-7-3-12(4-8-15)9-10-17/h1-8H,9,11H2
InChi Key
PXFUNIXWNXRVEJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $54

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    250 mg

    $127

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    500 mg

    $238

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    1 g

    $418

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    Product Description

    MDK35833 is an inducer of octamer-binding transcription factor 3/4 (Oct3/4) expression.1 It induces Oct3/4 expression in reporter assays using HEK or NCCIT cells when used at a concentration of 10 µM. MDK35833 (20 µM) induces expression of the genes encoding the pluripotency-associated proteins NANOG, REX1, and KLF4 in primary human fibroblasts.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, X., Dimou, E., Alborzinia, H., et al. Identification of 2-[4-[(4-Methoxyphenyl)methoxy]-phenyl]acetonitrile and derivatives as potent Oct3/4 inducers. J. Med. Chem. 58(12), 4976-4983 (2015).