A neurosteroid
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Isomer(s)
15728Dehydroepiandrosterone
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Etiocholanedione

Item No. 34358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5β)-androstane-3,17-dione
CAS Number
1229-12-5
Synonyms
  • 5β-Androstanedione
  • Etiocholane-3,17-dione
Molecular Formula
C19H28O2
Formula Weight
288.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
SMILES
C[C@@]12[C@]3([H])[C@](CC[C@]1([H])CC(CC2)=O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C
InChi Code
InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-16H,3-11H2,1-2H3/t12-,14+,15+,16+,18+,19+/m1/s1
InChi Key
RAJWOBJTTGJROA-QJISAEMRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Product Description

    Etiocholanedione is a neurosteroid.1 It inhibits glycine-induced chloride currents (IGly) in isolated rat hippocampal pyramidal neurons when used at a concentration of 50 µM. Etiocholanedione (0.1, 0.3, and 0.5 mM) also inhibits glucose exchange transport in isolated human erythrocytes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bukanova, J.V., SoIntserva, I., and Kudova, E. Neurosteroids as selective inhibitors of glycine receptor activity: Structure-activity relationship study on endogenous androstanes and androstenes. Front. Mol. Neurosci. 13, 44 (2020).

    2. Lacko, L., Wittke, B., and Geck, P. Interaction of steroids with the transport system of glucose in human erythrocytes. J. Cell. Physiol. 86 Suppl 2(3 Pt 2), 673-680 (1975).