An ionizable cationic lipidoid
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93-O17O

Item No. 34366

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-(tetradecyloxy)ethyl) 3,3'-((3-(1H-imidazol-1-yl)propyl)azanediyl)dipropionate
CAS Number
2227214-78-8
Molecular Formula
C44H83N3O6
Formula Weight
750.2
Purity
≥98%
Formulation (Request formulation change)
A 25 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: 25 mg/ml
SMILES
O=C(OCCOCCCCCCCCCCCCCC)CCN(CCCN1C=NC=C1)CCC(OCCOCCCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C44H83N3O6/c1-3-5-7-9-11-13-15-17-19-21-23-25-36-50-38-40-52-43(48)28-33-46(31-27-32-47-35-30-45-42-47)34-29-44(49)53-41-39-51-37-26-24-22-20-18-16-14-12-10-8-6-4-2/h30,35,42H,3-29,31-34,36-41H2,1-2H3
InChi Key
ZPJOKQMHTYTQFI-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $88

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    10 mg

    $168

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    25 mg

    $352

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    Cayman Chemical
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    Product Description

    93-O17O is a chalcogen-containing ionizable cationic lipidoid.1,2 It has been used in the generation of lipid nanoparticles (LNPs). LNPs containing 93-O17O localize to the spleen after intravenous injection into mice.1 LNPs containing 93-O17O have been used for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice and for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens.3,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhao, X., Chen, J., Qiu, M., et al. Imidazole-based synthetic lipidoids for in vivo mrna delivery into primary T lymphocytes. Angew. Chem. Int. Ed. Engl. 59(45), 20083-20089 (2020).

    2. Chen, J., Qiu, M., Ye, Z., et al. In situ cancer vaccination using lipidoid nanoparticles. Sci. Adv. 7(19), eabf1244 (2021).

    3. Li, Y., Yang, T., Yu, Y., et al. Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. Biomaterials 178, 652-662 (2018).