An ionizable cationic lipidoid
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93-O17S

Item No. 34367

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
bis(2-(tetradecylthio)ethyl) 3,3'-((3-(1H-imidazol-1-yl)propyl)azanediyl)dipropionate
CAS Number
2227008-67-3
Molecular Formula
C44H83N3O4S2
Formula Weight
782.3
Purity
≥95%
Formulation (Request formulation change)
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Chloroform: 100 mg/ml
SMILES
O=C(OCCSCCCCCCCCCCCCCC)CCN(CCCN1C=NC=C1)CCC(OCCSCCCCCCCCCCCCCC)=O
InChi Code
InChI=1S/C44H83N3O4S2/c1-3-5-7-9-11-13-15-17-19-21-23-25-38-52-40-36-50-43(48)28-33-46(31-27-32-47-35-30-45-42-47)34-29-44(49)51-37-41-53-39-26-24-22-20-18-16-14-12-10-8-6-4-2/h30,35,42H,3-29,31-34,36-41H2,1-2H3
InChi Key
OLOIOPYNTGMAAP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 mg

    $198

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    50 mg

    $377

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    100 mg

    $594

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    250 mg

    $1,386

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    Cayman Chemical
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    Product Description

    93-O17S is a chalcogen-containing ionizable cationic lipidoid.1 It has been used in the synthesis of lipid nanoparticles (LNPs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LNPs containing 93-O17S have been used for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes (STING) activation in a B16/F10 murine melanoma model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, Y., Yang, T., Yu, Y., et al. Combinatorial library of chalcogen-containing lipidoids for intracellular delivery of genome-editing proteins. Biomaterials 178, 652-662 (2018).

    2. Chen, J., Qiu, M., Ye, Z., et al. In situ cancer vaccination using lipidoid nanoparticles. Sci. Adv. 7(19), eabf1244 (2021).