A glycine-conjugated form of propionic acid
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Isomer(s)
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N-Propionylglycine

Item No. 34377

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1-oxopropyl)-glycine
CAS Number
21709-90-0
Synonyms
  • NSC 158539
Molecular Formula
C5H9NO3
Formula Weight
131.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 15 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(CNC(CC)=O)O
InChi Code
InChI=1S/C5H9NO3/c1-2-4(7)6-3-5(8)9/h2-3H2,1H3,(H,6,7)(H,8,9)
InChi Key
WOMAZEJKVZLLFE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $91

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    50 mg

    $169

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    100 mg

    $319

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    250 mg

    $751

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    Product Description

    N-Propionylglycine is a glycine-conjugated form of propionic acid.1 It is produced by glycine-N-acylase from propionyl-CoA, a catabolic intermediate that accumulates when the activity of propionyl-CoA carboxylase, the enzyme that converts propionyl-CoA to methylmalonyl-CoA, is deficient, in the mitochondria.1,2 Urinary levels of N-propionylglycine are increased in patients with propionic acidemia, an inborn error of metabolism characterized by vomiting, lethargy, protein intolerance, and failure to thrive.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Riemersma, M., Hazebroek, M.R., Helderman-van den Enden, A.T.J.M., et al. Propionic acidemia as a cause of adult-onset dilated cardiomyopathy. Eur. J. Hum. Genet. 25(11), 1195-1201 (2017).

    2. Fong, B.M.-W., Tam, S., and Leung, S.-Y. Quantification of acylglycines in human urine by HPLC electrospray ionization-tandem mass spectrometry and the establishment of pediatric reference interval in local Chinese. Talanta 88, 193-200 (2012).