An active metabolite of disulfiram
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Parent Compound(s)
15303Disulfiram
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Methyl Diethyldithiocarbamate

Item No. 34379

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-diethyl-carbamodithioic acid, methyl ester
CAS Number
686-07-7
Synonyms
  • DDTC-Me
  • Diethyldithiocarbamic Acid methyl ester
  • NSC 133269
Molecular Formula
C6H13NS2
Formula Weight
163.3
Purity
≥95%
Formulation (Request formulation change)
An oil
Solubility(Learn about Variance in Solubility)
Chloroform: slightly solubleMethanol: slightly soluble
SMILES
S=C(N(CC)CC)SC
InChi Code
InChI=1S/C6H13NS2/c1-4-7(5-2)6(8)9-3/h4-5H2,1-3H3
InChi Key
JYRXPFCUABYLPD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $66

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    50 mg

    $121

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    100 mg

    $203

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    250 mg

    $379

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    Product Description

    Methyl diethyldithiocarbamate is an active metabolite of the aldehyde dehydrogenase inhibitor disulfiram (Item No. 15303).1 It is produced by methylation of the disulfiram metabolite diethyldithiocarbamate in mouse liver microsomes.2 Methyl diethyldithiocarbamate inhibits liver low Km aldehyde dehydrogenase (ALDH) in rats (ID50 = 15.5 mg/kg).1 It decreases mean arterial pressure (MAP) and increases heart rate during ethanol challenge in rats when administered at a dose of 20.6 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hart, B.W., Yourick, J.J., and Faiman, M.D. S-methyl-N,N-diethylthiolcarbamate: A disulfiram metabolite and potent rat liver mitochondrial low Km aldehyde dehydrogenase inhibitor. Alcohol 7(2), 165-169 (1990).

    2. Gessner, T., and Jakubowski, M. Diethyldithiocarbamic acid methyl ester. A metabolite of disulfiram. Biochem. Pharmacol. 21(2), 219-230 (1972).