An adenosine A1 receptor agonist
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Adenosine amine congener

Item No. 34394

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[2-[[4-[2-[(2-aminoethyl)amino]-2-oxoethyl]phenyl]amino]-2-oxoethyl]phenyl]-adenosine
CAS Number
96760-69-9
Synonyms
  • ADAC
Molecular Formula
C28H32N8O6
Formula Weight
576.6
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
λmax
251, 304 nm
SMILES
O[C@H]1[C@](O[C@@H]([C@H]1O)CO)([H])N2C3=NC=NC(NC4=CC=C(C=C4)CC(NC5=CC=C(C=C5)CC(NCCN)=O)=O)=C3N=C2
InChi Code
InChI=1S/C28H32N8O6/c29-9-10-30-21(38)11-16-1-5-18(6-2-16)34-22(39)12-17-3-7-19(8-4-17)35-26-23-27(32-14-31-26)36(15-33-23)28-25(41)24(40)20(13-37)42-28/h1-8,14-15,20,24-25,28,37,40-41H,9-13,29H2,(H,30,38)(H,34,39)(H,31,32,35)/t20-,24-,25-,28-/m1/s1
InChi Key
JFRJCQJVFMHZOO-QZHHGCDDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Adenosine amine congener (ADAC) is an adenosine A1 receptor agonist.1,2 It selectively binds adenosine A1 over A2A and A3 receptors (Kis = 0.85, 210, and 281 nM, respectively, for the rat receptors).3 ADAC (75 µg/kg) increases survival and prevents neuronal damage in the hippocampal CA1 region in a gerbil model of cerebral ischemia induced by bilateral carotid artery occlusion.1 It protects against auditory threshold shifts and inner and outer hair cell loss in rats following noise exposure at 110 dB when administered at a dose of 100 µg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Von Lubitz, D.K.J.E., Lin, R.C.-S., Bischofberger, N., et al. Protection against ischemic damage by adenosine amine congener, a potent and selective adenosine A1 receptor agonist. Eur. J. Pharmacol. 369(3), 313-317 (1999).

    2. Vlajkovic, S.M., Lee, K.-H., Wong, A.C.Y., et al. Adenosine amine congener mitigates noise-induced cochlear injury. Purinergic Signal. 6(2), 273-281 (2010).

    3. Karl, M.O., Fleischhauer, J.C., Stamer, W.D., et al. Differential P1-purinergic modulation of human Schlemm’s canal inner-wall cells. Am. J. Physiol. Cell Physiol. 288(4), C784-C794 (2005).