A positive allosteric modulator of mGluR5
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DFB

Item No. 34395

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(3-fluorophenyl)methylene]hydrazone, 3-fluoro-benzaldehyde
CAS Number
15332-10-2
Synonyms
  • 3,3'-Difluorobenzaldazine
Molecular Formula
C14H10F2N2
Formula Weight
244.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 1 mg/ml
λmax
300, 312 nm
SMILES
FC1=CC=CC(C=NN=CC2=CC(F)=CC=C2)=C1
InChi Code
InChI=1S/C14H10F2N2/c15-13-5-1-3-11(7-13)9-17-18-10-12-4-2-6-14(16)8-12/h1-10H
InChi Key
YYMCVDNIIFNDJK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $110

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    25 mg

    $257

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    50 mg

    $481

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    Product Description

    DFB is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5).1 It potentiates glutamate-, quisqualate-, or 3,5-dihydroxyphenylglycine-induced calcium transients in CHO cells expressing human mGluR5 (EC50s = 0.021, 0.642, and 2.4 µM, respectively). It also enhances quisqualate-induced phosphatidylinositol hydrolysis in rat hippocampal slices (EC50 = 0.42 µM). DFB improves spatial alternation retention in the Y-maze special alternation task in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. O'Brien, J.A., Lemaire, W., Chen, T.-B., et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol. Pharmacol. 64(3), 731-740 (2003).

    2. Balschun, D., Zuschratter, W., and Wetzel, W. Allosteric enhancement of metabotropic glutamate receptor 5 function promotes spatial memory. Neuroscience 142(3), 691-702 (2006).