A positive allosteric modulator of M1 mAChRs
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MK-7622

Item No. 34407

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methyl-3-pyridinyl)methyl]-benzo[h]quinazolin-4(3H)-one
CAS Number
1227923-29-6
Molecular Formula
C25H25N3O2
Formula Weight
399.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMF:PBS (pH 7.2) (1:4): 0.20 mg/mlDMSO: 1 mg/mlEthanol: 1 mg/ml
λmax
252 nm
SMILES
O=C1C2=CC(CC3=CN=C(C)C=C3)=C(C=CC=C4)C4=C2N=CN1[C@H]5CCCC[C@@H]5O
InChi Code
InChI=1S/C25H25N3O2/c1-16-10-11-17(14-26-16)12-18-13-21-24(20-7-3-2-6-19(18)20)27-15-28(25(21)30)22-8-4-5-9-23(22)29/h2-3,6-7,10-11,13-15,22-23,29H,4-5,8-9,12H2,1H3/t22-,23-/m0/s1
InChi Key
JUVQLZBJFOGEEO-GOTSBHOMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $93

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    10 mg

    $154

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    25 mg

    $316

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    50 mg

    $585

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    Product Description

    MK-7622 is a positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs).1 It increases ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM). MK-7622 (0.3 and 1 mg/kg) reverses scopolamine-induced cognitive deficits in an object retrieval detour task in rhesus macaques.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Uslaner, J.M., Kuduk, S.D., Wittmann, M., et al. Preclinical to human translational pharmacology of the novel M1 positive allosteric modulator MK-7622. J. Pharmacol. Exp. Ther. 365(3), 556-566 (2018).