A cephalosporin antibiotic
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Cefoselis (sulfate)

Item No. 34414

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosulfate
CAS Number
122841-12-7
Synonyms
  • FK-037
Molecular Formula
C19H22N8O6S2 • H2SO4
Formula Weight
620.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
λmax
261 nm
SMILES
O=S(O)(O)=O.CO/N=C(C1=CSC(N)=N1)\C(N[C@H]2[C@](SCC(CN3N(CCO)C(C=C3)=N)=C4C(O)=O)([H])N4C2=O)=O
InChi Code
InChI=1S/C19H22N8O6S2.H2O4S/c1-33-24-12(10-8-35-19(21)22-10)15(29)23-13-16(30)27-14(18(31)32)9(7-34-17(13)27)6-25-3-2-11(20)26(25)4-5-28;1-5(2,3)4/h2-3,8,13,17,20,28H,4-7H2,1H3,(H2,21,22)(H,23,29)(H,31,32);(H2,1,2,3,4)/b20-11?,24-12-;/t13-,17-;/m1./s1
InChi Key
LZOLCSVRFKCSEM-ZQCAECPKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    Cefoselis is a cephalosporin antibiotic.1 It is active against clinical isolates of extended-spectrum β-lactamase-producing E. coli, K. pneumoniae, and P. mirabilis, as well as C. freundii, E. aerogenes, E. cloacae, S. marcescens, and P. vulgaris with susceptibility rates ranging from 56.7 to greater than 94%. Cefoselis is protective against lethality in mouse models of systemic methicillin-susceptible S. aureus (MSSA), low-level methicillin-resistant S. aureus (L-MRSA), high-level methicillin-resistant S. aureus (H-MRSA), S. pneumoniae, E. coli, K. pneumoniae, or P. aeruginosa infection (ED50s = ≤0.025-1.56 mg/kg).2 It reduces the number of renal colony forming units (CFUs) in a mouse model of S. epidermidis-induced ascending pyelonephritis when administered at a dose of 50 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng, J.-W., Su, J.-R., Xiao, M., et al. In vitro activity of a new fourth-generation cephalosporin, cefoselis, against clinically important bacterial pathogens in China. Front. Microbiol. 11, 180 (2020).

    2. Mine, Y., Watanabe, Y., Sakamoto, H., et al. In vivo antibacterial activity of FK037, a novel parenteral broad-spectrum cephalosporin. J Antibiot. (Tokyo) 46(1), 88-98 (1993).