A typical antipsychotic
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Acetophenazine (maleate)

Item No. 34415

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[10-[3-[4-(2-hydroxyethyl)-1-piperazinyl]propyl]-10H-phenothiazin-2-yl]-ethanone, dimaleate
CAS Number
5714-00-1
Synonyms
  • NSC 70600
  • NSC 169180
Molecular Formula
C23H29N3O2S • 2C4H4O4
Formula Weight
643.7
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
244, 279 nm
SMILES
OC(/C=C\C(O)=O)=O.OCCN(CC1)CCN1CCCN2C3=CC(C(C)=O)=CC=C3SC4=CC=CC=C42.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C23H29N3O2S.2C4H4O4/c1-18(28)19-7-8-23-21(17-19)26(20-5-2-3-6-22(20)29-23)10-4-9-24-11-13-25(14-12-24)15-16-27;2*5-3(6)1-2-4(7)8/h2-3,5-8,17,27H,4,9-16H2,1H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChi Key
NUKVZKPNSKJGBK-SPIKMXEPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    25 mg

    $81

    Add

    50 mg

    $128

    Add

    100 mg

    $193

    Add
    Product Description

    Acetophenazine is a typical antipsychotic that binds to the serotonin (5-HT) receptor subtypes 5-HT6 and 5-HT7 and the androgen receptor (Kis = 72, 2.4, and 800 nM, respectively).1,2 Acetophenazine also inhibits the binding of the sigma receptor agonist SKF 10047 (Ki = 36 nM) and the dopamine D2-selective antagonist spiperone (IC50 = 17 nM) to guinea pig brain membranes.3 It increases the duration of fighting and the latency to submission in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roth, B.L., Craigo, S.C., Choudhary, M.S., et al. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. J. Pharmacol. Exp. Ther. 268(3), 1403-1410 (1994).

    2. Bisson, W.H., Cheltsov, A.V., Bruey-Sedano, N., et al. Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proc. Natl. Acad. Sci. USA 104(29), 11927-11932 (2007).

    3. Tam, S.W., and Cook, L. σ opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. Proc. Natl. Acad. Sci. USA 81(17), 5618-5621 (1984).

    4. Knight, W.R., Holtz, J.R., and Sprogis, G.R. Acetophenazine and fighting behavior in mice. Science 141(3583), 830-831 (1963).