A peptide with diverse biological activities
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Litorin (trifluoroacetate salt)

Item No. 34427

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-oxo-L-prolyl-L-glutaminyl-L-tryptophyl-L-alanyl-L-valylglycyl-L-histidyl-L-phenylalanyl-L-methioninamide, trifluoroacetate salt
Synonyms
  • pyroGlu-Gln-Trp-Ala-Val-Gly-His-Phe-Met-NH2
  • Pyr-EQWAVGHFM-NH2
Molecular Formula
C51H68N14O11S • XCF3COOH
Formula Weight
1085.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: soluble
SMILES
O=C([C@H]1NC(CC1)=O)N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](C(C)C)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCSC)=O)CC2=CC=CC=C2)=O)CC3=CN=CN3)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C51H68N14O11S.C2HF3O2/c1-27(2)43(51(76)56-25-42(68)60-39(22-31-24-54-26-57-31)50(75)63-37(20-29-10-6-5-7-11-29)49(74)61-34(44(53)69)18-19-77-4)65-45(70)28(3)58-48(73)38(21-30-23-55-33-13-9-8-12-32(30)33)64-47(72)36(14-16-40(52)66)62-46(71)35-15-17-41(67)59-35;3-2(4,5)1(6)7/h5-13,23-24,26-28,34-39,43,55H,14-22,25H2,1-4H3,(H2,52,66)(H2,53,69)(H,54,57)(H,56,76)(H,58,73)(H,59,67)(H,60,68)(H,61,74)(H,62,71)(H,63,75)(H,64,72)(H,65,70);(H,6,7)/t28-,34-,35-,36-,37-,38-,39-,43-;/m0./s1
InChi Key
VQCATNJVVYBYPQ-KJCVQWSBSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $95

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    5 mg

    $392

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    10 mg

    $647

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    Product Description

    Litorin is a peptide originally isolated from L. aurea that has diverse biological activities.1,2,3,4 It is an agonist of the gastrin-releasing peptide receptor (GRPR) and the neuromedin B (NMB) receptor in BALB/c 3T3 fibroblasts expressing the human receptors (EC50s = 0.44 and 0.03 nM, respectively) and binds to frog bombesin receptor subtype 4 (BB4) in CHO-K1 cells (Ki = 1.2 nM).2,3 Litorin (10-100 ng/kg) induces contractions of isolated guinea pig gallbladder.4 It decreases food intake in rats when administered at doses ranging from 4 to 128 µg/kg.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kulkosky, P.J., and Gibbs, J. Litorin suppresses food intake in rats. Life Sci. 31(7), 685-692 (1982).

    2. Uehara, H., González, N., Sancho, V., et al. Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs. Peptides 32(8), 1685-1699 (2011).

    3. Katsuno, T., Pradhan, T.K., Ryan, R.R., et al. Pharmacology and cell biology of the bombesin receptor subtype 4 (BB4-R). Biochemistry 38(22), 7307-7320 (1999).

    4. Endean, R., Erspamer, V., Falconieri Erspamer, G., et al. Parallel bioassay of bombesin and litorin, a bombesin-like peptide from the skin of Litoria aurea. Br. J. Pharmacol. 55(2), 213-219 (1975).