A sesquiterpene with antimicrobial and anticancer activities
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Isomer(s)
35270Thujopsene
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(+)-δ-Cadinene

Item No. 34444

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1S,2,3,5,6,8aR-hexahydro-4,7-dimethyl-1-(1-methylethyl)-naphthalene
CAS Number
483-76-1
Molecular Formula
C15H24
Formula Weight
204.4
Purity
≥95%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
250 nm
SMILES
CC([C@H]1[C@@]2([H])C(CCC(C)=C2)=C(CC1)C)C
InChi Code
InChI=1S/C15H24/c1-10(2)13-8-6-12(4)14-7-5-11(3)9-15(13)14/h9-10,13,15H,5-8H2,1-4H3/t13-,15-/m0/s1
InChi Key
FUCYIEXQVQJBKY-ZFWWWQNUSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

    $46

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    1 g

    $181

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    Product Description

    (+)-δ-Cadinene is a sesquiterpene that has been found in upland cotton (G. hirsutum) and has antibacterial, insecticidal, and anticancer activities.1,2,3,4 It is active against S. pneumoniae (MIC = 31.25 µg/ml) and induces mortality in A. stephensi, A. aegypti, and C. quinquefasciatus third instar larvae (LC50s = 8.23, 9.03, and 9.86 µg/ml, respectively).2,3 (+)-δ-Cadinene (10, 50, and 100 µM) induces apoptosis in and inhibits proliferation of OVCAR-3 human ovarian cancer cells.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Davis, G.D., and Essenberg, M. (+)-δ-Cadinene is a product of sesquiterpene cyclase activity in cotton. Phytochemistry 39(3), 553-567 (1995).

    2. Pérez-López, A., Cirio, A.T., Rivas-Galindo, V.M., et al. Activity against Streptococcus pneumoniae of the essential oil and δ-cadinene isolated from Schinus molle fruit. J. Essent. Oil Res. 23(5), 25-28 (2011).

    3. Govindarajan, M., Rajeswary, M., and Benelli, G. δ-Cadinene, calarene and δ-4-carene from Kadsura heteroclita essential oil as novel larvicides against malaria, dengue and filariasis mosquitoes. Comb. Chem. High Throughput Screen. 19(7), 565-571 (2016).

    4. Hui, L.-M., Zhao, G.-D., and Zhao, J.-J. δ-Cadinene inhibits the growth of ovarian cancer cells via caspase-dependent apoptosis and cell cycle arrest. Int. J. Clin. Exp. Pathol. 8(6), 6046-6056 (2015).