A fluorogenic substrate for DPP-4
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GP-AMC (hydrobromide)

Item No. 34458

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-prolinamide, monohydrobromide
CAS Number
115035-46-6
Synonyms
  • Gly-Pro-AMC
  • Gly-Pro-7-amido-4-methylcoumarin
Molecular Formula
C17H19N3O4 • HBr
Formula Weight
410.3
Purity
≥98%
Emission
440-460 nm
Excitation
340-360 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
328 nm
SMILES
CC(C1=CC=C(NC([C@H]2N(C(CN)=O)CCC2)=O)C=C1O3)=CC3=O.Br
InChi Code
InChI=1S/C17H19N3O4.BrH/c1-10-7-16(22)24-14-8-11(4-5-12(10)14)19-17(23)13-3-2-6-20(13)15(21)9-18;/h4-5,7-8,13H,2-3,6,9,18H2,1H3,(H,19,23);1H/t13-;/m0./s1
InChi Key
PASXTQMFJRHMLJ-ZOWNYOTGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $103

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    10 mg

    $194

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    25 mg

    $454

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    50 mg

    $801

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    Product Description

    GP-AMC is a fluorogenic substrate for dipeptidyl peptidase 4 (DPP-4).1,2 Upon enzymatic cleavage by DPP-4, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify DPP-4 activity. AMC displays excitation/emission maxima of 340-360/440-460 nm, respectively.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matheeussen, V., Lambeir, A.-M., Jungraithmayr, W., et al. Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors. Clin. Chim. Acta 413(3-4), 456-462 (2012).

    2. Lammi, C., Bollati, C., Ferruzza, S., et al. Soybean- and lupin-derived peptides inhibit DPP-IV activity on in situ human intestinal Caco-2 cells and ex vivo human serum. Nutrients 10(8), 1082 (2018).