A sulfonated azo dye with antiviral activity
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Brilliant Black BN

Item No. 34462

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(acetylamino)-5-hydroxy-6-[2-[7-sulfo-4-[2-(4-sulfophenyl)diazenyl]-1-naphthalenyl]diazenyl]-1,7-naphthalenedisulfonic acid, tetrasodium salt
CAS Number
2519-30-4
Synonyms
  • CI 28440
  • E151
Molecular Formula
C28H17N5O14S4 • 4Na
Formula Weight
867.7
Purity
≥60%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(NC(C(C(O)=C1N=NC(C2=C3C=CC([S](=O)([O-])=O)=C2)=CC=C3N=NC(C=C4)=CC=C4[S](=O)([O-])=O)=C5C=C1[S](=O)([O-])=O)=CC=C5[S](=O)([O-])=O)=O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C28H21N5O14S4.4Na/c1-14(34)29-23-10-11-24(50(42,43)44)20-13-25(51(45,46)47)27(28(35)26(20)23)33-32-22-9-8-21(18-7-6-17(12-19(18)22)49(39,40)41)31-30-15-2-4-16(5-3-15)48(36,37)38;;;;/h2-13,35H,1H3,(H,29,34)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47);;;;/q;4*+1/p-4
InChi Key
GMMAPXRGRVJYJY-UHFFFAOYSA-J
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Brilliant black BN is a sulfonated azo dye with antiviral activity.1,2 It reduces the infectivity of enterovirus 71 (EV71) in rhabdomyosarcoma cells (IC50 = 10.1 µM) via inhibition of viral entry.2 Formulations containing brilliant black BN have commonly been used as food color additives.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Macioszek, V.K., and Kononowicz, A.K. The evaluation of the genotoxicity of two commonly used food colors: Quinoline yellow (E 104) and brilliant black BN (E 151). Cell. Mol. Biol. Lett. 9(1), 107-122 (2004).

    2. Meng, T., Jia, Q., Wong, S.-M., et al. In vitro and in vivo inhibition of the infectivity of human enterovirus 71 by a sulfonated food azo dye, brilliant black BN. J. Virol. 93(17), e00061-00019 (2019).