An inhibitor of caspase-1, -4, -5, and -11
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Ac-FLTD-CMK (trifluoroacetate salt)

Item No. 34469

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S,7S,10S,13S)-4-benzyl-13-(2-chloroacetyl)-10-((R)-1-hydroxyethyl)-7-isobutyl-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid, trifluoroacetate salt
Synonyms
  • Ac-Phe-Leu-Thr-Asp-CMK
Molecular Formula
C26H37ClN4O8 • XCF3COOH
Formula Weight
569.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml
SMILES
ClCC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC(C)C)NC([C@@H](NC(C)=O)CC1=CC=CC=C1)=O)=O)=O)=O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C26H37ClN4O8.C2HF3O2/c1-14(2)10-19(30-24(37)20(28-16(4)33)11-17-8-6-5-7-9-17)25(38)31-23(15(3)32)26(39)29-18(12-22(35)36)21(34)13-27;3-2(4,5)1(6)7/h5-9,14-15,18-20,23,32H,10-13H2,1-4H3,(H,28,33)(H,29,39)(H,30,37)(H,31,38)(H,35,36);(H,6,7)/t15-,18+,19+,20+,23+;/m1./s1
InChi Key
XJCUHBUOWTWTOV-DXXINTPRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $468

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    Product Description

    Ac-FLTD-CMK is an inhibitor of caspase-1, -4, -5, and -11.1 It inhibits caspase-1, -4, and -5 (IC50s = 0.0467, 1.49, and 0.329, respectively, for the recombinant human enzymes) and cleavage of gasdermin D (GSDMD), an effector involved in pyroptosis and NETosis, by mouse caspase-11 when used at a concentration of 10 µM. Ac-FLTD-CMK (10 µM) inhibits LPS- and ATP- or LPS- and nigericin-induced pyroptosis and IL-1β release in mouse bone marrow-derived macrophages (BMDMs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, J., Liu, Z., Wang, C., et al. Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor. Proc. Natl. Acad. Sci. USA 115(26), 6792-6797 (2018).