An anthraquinone glycoside with diverse biological activities
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Emodin 8-glucoside

Item No. 34474

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(β-D-glucopyranosyloxy)-3,8-dihydroxy-6-methyl-9,10-anthracenedione
CAS Number
23313-21-5
Synonyms
  • Emodin 8-O-β-D-glucopyranoside
  • Emodin 8-β-D-glucoside
  • NSC 257449
Molecular Formula
C21H20O10
Formula Weight
432.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml
λmax
224, 283 nm
SMILES
O=C(C1=CC(C)=CC(O)=C12)C3=CC(O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C3C2=O
InChi Code
InChI=1S/C21H20O10/c1-7-2-9-14(11(24)3-7)18(27)15-10(16(9)25)4-8(23)5-12(15)30-21-20(29)19(28)17(26)13(6-22)31-21/h2-5,13,17,19-24,26,28-29H,6H2,1H3/t13-,17-,19+,20-,21-/m1/s1
InChi Key
HSWIRQIYASIOBE-JNHRPPPUSA-N
Origin
Plant/Rhei Radix Et Rhizoma
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $134

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    5 mg

    $266

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    10 mg

    $466

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    Product Description

    Emodin 8-glucoside is an anthraquinone glycoside that has been found in R. japonica and has diverse biological activities.1,2,3,4 It inhibits the activities of rat lens aldose reductase and human DNA topoisomerase II (IC50s = 14.4 and 66 μM, respectively, in cell-free assays).1,2 Emodin 8-glucoside (1 ng/ml) promotes the proliferation and differentiation of mouse MC3T3-E1 osteoblastic cells.3 It also decreases infarct size in a rat model of focal cerebral ischemia and reperfusion injury when administered at a dose of 5 mg/kg.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, J.M., Jamg, D.S., Lee, Y.M., et al. Constituents of the fruits of Rumex japonicus with inhibitory activity on aldose reductase. J. Appl. Biol. Chem. 51(1), 13-16 (2008).

    2. Hwangbo, K., Zheng, M.S., Kim, Y.-J., et al. Inhibition of DNA topoisomerases I and II of compounds from Reynoutria japonica. Arch. Pharm. Res. 35(9), 1583-1589 (2012).

    3. Xiang, M.-X., Xu, Z., Su, H.-W., et al. Emodin-8-O-β-D-glucoside from Polygonum amplexicaule D. Don var. sinense Forb. promotes proliferation and differentiation of osteoblastic MC3T3-E1 cells. Molecules 16(1), 728-737 (2011).

    4. Wang, C., Zhang, D., Ma, H., et al. Neuroprotective effects of emodin-8-O-β-D-glucoside in vivo and in vitro. Eur. J. Pharmacol. 577(1-3), 58-63 (2007).