A specialized pro-resolving mediator
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Resolvin D2 n-3 DPA

Item No. 34482

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7S,16R,17S-trihydroxy-8E,10Z,12E,14E,19Z-docosapentaenoic acid
CAS Number
2093111-29-4
Synonyms
  • 7(S),16(R),17(S)-Resolvin D2 n-3 DPA
  • RvD2 n-3 DPA
Molecular Formula
C22H34O5
Formula Weight
378.5
Purity
≥98%
Formulation (Request formulation change)
A 50 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
λmax
289, 302, 317 nm
SMILES
O[C@H](/C=C/C=C\C=C\C=C\[C@@H](O)[C@@H](O)C/C=C\CC)CCCCCC(O)=O
InChi Code
InChI=1S/C22H34O5/c1-2-3-9-16-20(24)21(25)17-12-7-5-4-6-10-14-19(23)15-11-8-13-18-22(26)27/h3-7,9-10,12,14,17,19-21,23-25H,2,8,11,13,15-16,18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,14-10+,17-12+/t19-,20+,21-/m1/s1
InChi Key
LDVCZYSUILUYKN-BGERNTNVSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 µg

    $169

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    25 µg

    $400

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    50 µg

    $758

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    100 µg

    $1,347

    Add
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    Product Description

    Resolvin D2 n-3 DPA (RvD2 n-3 DPA) is a specialized pro-resolving mediator (SPM).1 It is formed from docosapentaenoic acid (n-3 DPA; Item Nos. 90165 | 21907), an intermediate in the conversion of eicosapentaenoic acid (Item Nos. 90110 | 90110.1 | 21908) to docosahexaenoic acid (Item Nos. 90310 | 17950), in human leukocytes. RvD2 n-3 DPA (1 nM) reduces TNF-α-induced chemotaxis and adhesion of isolated human neutrophils. In vivo, RvD2 n-3 DPA (100 ng/animal; i.v.) reduces peritoneal neutrophil infiltration and exudate levels of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in a mouse model of zymosan-induced inflammation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dalli, J., Colas, R.A., and Serhan, C.N. Novel n-3 immunoresolvents: Structures and actions. Sci. Rep. 3, 1940 (2013).