A penem antibiotic
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Faropenem (sodium salt hydrate)

Item No. 34507

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, monosodium salt, pentahydrate
CAS Number
158365-51-6
Molecular Formula
C12H14NO5S • Na [2.5H2O]
Formula Weight
352.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
263, 304 nm
SMILES
[O-]C(C1=C([C@]2([H])OCCC2)S[C@@]([C@@]3([H])[C@H](O)C)([H])N1C3=O)=O.[O-]C(C4=C([C@]5([H])OCCC5)S[C@@]([C@@]6([H])[C@H](O)C)([H])N4C6=O)=O.[Na+].O.O.O.O.O.[Na+]
InChi Code
InChI=1S/2C12H15NO5S.2Na.5H2O/c2*1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6;;;;;;;/h2*5-7,11,14H,2-4H2,1H3,(H,16,17);;;5*1H2/q;;2*+1;;;;;/p-2/t2*5-,6-,7+,11-;;;;;;;/m11......./s1
InChi Key
MOGICMVNWAUWMK-HIXRZVNASA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Cayman Chemical
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    Product Description

    Faropenem is a broad-spectrum penem antibiotic.1 It is active against a panel of 12 Gram-positive (MIC50s = 0.008-1 mg/L) and 15 Gram-negative (MIC50s = 0.06-16 mg/L) bacteria. Faropenem (20 mg/kg) reduces the number of lung colony forming units (CFUs) in a mouse model of H. influenzae-induced respiratory tract infection.2 Formulations containing faropenem have been used in the treatment of various bacterial infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schurek, K.N., Wiebe, R., Karlowsky, J.a., et al. Faropenem: Review of a new oral penem. Expert Rev. Anti. Infect. Ther. 5(2), 185-198 (2007).

    2. Miyazaki, S., Hosoyama, T., Furuya, N., et al. In vitro and in vivo antibacterial activities of L-084, a novel oral carbapenem, against causative organisms of respiratory tract infections. Antimicrob. Agents Chemother. 45(1), 203-207 (2001).