A non-enzymatically derived oxylipin
Related Products
Enantiomer(s)
3450511(R)-HETE
Isomer(s)
34500(±)11-HETE
Technical Support & Resources

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11(S)-HETE

Item No. 34510

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11S-hydroxy-5Z,8Z,12E,14Z-eicosatetraenoic acid
CAS Number
54886-50-9
Synonyms
  • 11(S)-Hydroxyeicosatetraenoic Acid
Molecular Formula
C20H32O3
Formula Weight
320.5
Purity
≥98%
Formulation (Request formulation change)
A solution in ethanol
Solubility(Learn about Variance in Solubility)
0.1 M Na2CO3: 2 mg/mlDMF: MiscibleDMSO: MiscibleEthanol: MisciblePBS pH 7.2: 0.8 mg/ml
λmax
236 nm
SMILES
CCCCC/C=C\C=C/[C@@H](O)C/C=C\C/C=C\CCCC(=O)O
InChi Code
InChI=1S/C20H32O3/c1-2-3-4-5-7-10-13-16-19(21)17-14-11-8-6-9-12-15-18-20(22)23/h6-7,9-11,13-14,16,19,21H,2-5,8,12,15,17-18H2,1H3,(H,22,23)/b9-6-,10-7-,14-11-,16-13+/t19-/m1/s1
InChi Key
GCZRCCHPLVMMJE-YZGNWCGPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

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    Product Description

    11(S)-HETE is an oxylipin and the (S) enantiomer of 11(R)-HETE (Item No. 34505). It is formed non-enzymatically from arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).1 Levels of 11(S)-HETE are higher than those of 11(R)-HETE in isolated human plasma and serum and in LPS-stimulated isolated human plasma. Serum labels of 11(S)-HETE decrease in patients with allergic rhinitis after one year of double-mite subcutaneous immunotherapy (DM-SCIT) and are associated with an improved quality of life in regards to rhinoconjunctivitis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mazaleuskaya, L.L., Salamatipour, A., Saratopoulou, D., et al. Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J. Lipid Res. 59(3), 564-575 (2018).

    2. Zheng, P., Yan, G., Zhang, Y., et al. Metabolomics reveals process of allergic rhinitis patients with single- and double-species mite subcutaneous immunotherapy. Metabolites 11(9), 613 (2021).

    Product Citations

    Wu, Z., Xiao, H., Rao, D., et al. Analytical strategy for oxylipin annotation by combining chemical derivatization-based retention index algorithm and feature tandem mass spectrometric fragmentation as a biomarker discovery tool. Anal. Chem. 95(43), 15933-15942 (2023).

    Rao, C.V., Desai, D., Rivenson, A., et al. Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate. Cancer Res. 55(11), 2310-2315 (1995).