An internal standard for the quantification of vincristine
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Unlabeled Version(s)
11764Vincristine (sulfate)
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Vincristine-d3

Item No. 34512

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
22-oxo-vincaleukoblastine-d3
CAS Number
1246817-09-3
Synonyms
  • Kyocristine-d3
  • Leurocristine-d3
  • Lilly 37231-d3
  • Novopharm-d3
  • VCR-d3
Molecular Formula
C46H53D3N4O10
Formula Weight
828.0
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: solubleMethanol: soluble
SMILES
CC[C@]1([C@H]2OC(C([2H])([2H])[2H])=O)[C@@]3([H])[C@](C(C4=C5)=CC([C@](C6=C7C8=CC=CC=C8N6)(C[C@](C[C@@]9(O)CC)([H])C[N@@](C9)CC7)C(OC)=O)=C5OC)(CCN3CC=C1)[C@](N4C=O)([H])[C@@]2(O)C(OC)=O
InChi Code
InChI=1S/C46H56N4O10/c1-7-42(55)22-28-23-45(40(53)58-5,36-30(14-18-48(24-28)25-42)29-12-9-10-13-33(29)47-36)32-20-31-34(21-35(32)57-4)50(26-51)38-44(31)16-19-49-17-11-15-43(8-2,37(44)49)39(60-27(3)52)46(38,56)41(54)59-6/h9-13,15,20-21,26,28,37-39,47,55-56H,7-8,14,16-19,22-25H2,1-6H3/t28-,37+,38-,39-,42+,43-,44-,45+,46+/m1/s1/i3D3
InChi Key
OGWKCGZFUXNPDA-GBBJZFCTSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $411

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    Product Description

    Vincristine-d3 is intended for use as an internal standard for the quantification of vincristine (Item No. 11764) by GC- or LC-MS. Vincristine is a vinca alkaloid that has been found in C. rosea and has anticancer activities.1,2 It inhibits tubulin polymerization in a cell-free assay (Ki = 0.085 µM) and induces mitotic arrest in U937 cells when used at a concentration of 10 nM. In vivo, vincristine (3 mg/kg) reduces tumor growth in rhabdomyosarcoma patient-derived xenograft (PDX) mouse models.3 Formulations containing vincristine have been used in the treatment of various cancers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jordan, M.A., Himes, R.H., and Wilson, L. Comparison of the effects of vinblastine, vincristine, vindesine, and vinepidine on microtubule dynamics and cell proliferation in vitro. Cancer Res. 45(6), 2741-2747 (1985).

    2. Towle, M.J., Salvato, K.A., Wels, B.F., et al. Eribulin induces irreversible mitotic blockade: Implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions. Cancer Res. 71(2), 496-505 (2011).

    3. Horton, J.K., Houghton, P.J., and Houghton, J.A. Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts. Biochem. Pharmacol. 37(20), 3995-4000 (1988).