A saponin with diverse biological activities
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Gypenoside XVII

Item No. 34514

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3β-(β-D-glucopyranosyloxy)-12β-hydroxydammar-24-en-20-yl 6-O-β-D-glucopyranosyl-β-D-glucopyranoside
CAS Number
80321-69-3
Synonyms
  • Gyp-17
  • Gyp-XVII
  • Gynosaponin S
Molecular Formula
C48H82O18
Formula Weight
947.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:1): 0.20 mg/mlDMSO: 5 mg/ml
SMILES
C[C@]12[C@]3([C@@]([C@@H](C[C@]1([H])[C@@]4([C@@](C(C)([C@H](CC4)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5O)O)O)CO)C)([H])CC2)C)O)([H])[C@]([C@](O[C@@H]6O[C@H](CO[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O)[C@H]6O)(C)CC/C=C(C)/C)([H])CC3)C
InChi Code
InChI=1S/C48H82O18/c1-22(2)10-9-14-48(8,66-43-40(60)37(57)34(54)27(64-43)21-61-41-38(58)35(55)32(52)25(19-49)62-41)23-11-16-47(7)31(23)24(51)18-29-45(5)15-13-30(44(3,4)28(45)12-17-46(29,47)6)65-42-39(59)36(56)33(53)26(20-50)63-42/h10,23-43,49-60H,9,11-21H2,1-8H3/t23-,24+,25+,26+,27+,28-,29+,30-,31-,32+,33+,34+,35-,36-,37-,38+,39+,40+,41+,42-,43-,45-,46+,47+,48-/m0/s1
InChi Key
ZRBFCAALKKNCJG-SJYBZOGZSA-N
Origin
Plant/Gynostemma pentaphyllum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

    $233

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    10 mg

    $427

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    25 mg

    $983

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    Product Description

    Gypenoside XVII is a saponin that has been found in P. notoginseng and has diverse biological activities.1,2,3,4 It induces autophagic clearance of amyloid-β precursor protein (APP), Aβ40, and Aβ42 in PC12 cells expressing Swedish mutant APP isoform 695 (APP695 Swe) when used at a concentration of 10 µM.1 Gypenoside XVII (40 mg/kg) prevents the formation of hippocampal and cortical Aβ plaques and ameliorates spatial cognitive deficits in the transgenic APP/PS1 mouse model of Alzheimer's disease. It decreases lipid deposition in the aortic sinus and serum levels of malondialdehyde (MDA), reduces aortic plaque area, and increases serum levels of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase in ApoE-/- mice.2 Gypenoside XVII (10 and 50 mg/kg) reduces spinal cord edema and neuronal apoptosis in a mouse model of mechanical compression-induced spinal cord injury.3 It also maintains retinal permeability and structure and reduces retinal levels of apoptotic proteins in a db/db mouse model of early diabetic retinopathy.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meng, X., Luo, Y., Liang, T., et al. Gypenoside XVII enhances lysosome biogenesis and autophagy flux and accelerates autophagic clearance of amyloid-β through TFEB activation. J. Alzheimers Dis. 52(3), 1135-1150 (2016).

    2. Yang, K., Zhang, H., Luo, Y., et al. Gypenoside XVII prevents atherosclerosis by attenuating endothelial apoptosis and oxidative stress: Insight into the ERα-mediated PI3K/Akt pathway. Int. J. Mol. Sci. 18(2), 77 (2017).

    3. Sun, T., Duan, L., Li, J., et al. Gypenoside XVII protects against spinal cord injury in mice by regulating the microRNA‑21‑mediated PTEN/AKT/mTOR pathway. Int. J. Mol. Med. 48(2), 146 (2021).

    4. Luo, Y., Dong, X., Lu, S., et al. Gypenoside XVII alleviates early diabetic retinopathy by regulating Müller cell apoptosis and autophagy in db/db mice. Eur. J. Pharmacol. 895, 173893 (2021).