A degrader of GSPT1 and GSPT2
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Product Type

Biochemicals

Research Area

Cancer
Cell Death

SJ6986

Item No. 34523

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-2-(trifluoromethoxy)-benzenesulfonamide
CAS Number
2765625-93-0
Molecular Formula
C20H14F3N3O7S
Formula Weight
497.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
λmax
237 nm
SMILES
FC(F)(F)OC1=CC=CC=C1S(NC2=CC3=C(C(N(C4C(NC(CC4)=O)=O)C3=O)=O)C=C2)(=O)=O
InChi Code
InChI=1S/C20H14F3N3O7S/c21-20(22,23)33-14-3-1-2-4-15(14)34(31,32)25-10-5-6-11-12(9-10)19(30)26(18(11)29)13-7-8-16(27)24-17(13)28/h1-6,9,13,25H,7-8H2,(H,24,27,28)
InChi Key
RKAFYSIKAVFVPS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    Product Description

    SJ6986 is a degrader of G1 to S phase transition 1 (GSPT1) and GSPT2.1 It reduces the levels of GSPT1 and GSPT2 in MV4-11 cells in a concentration-dependent manner. SJ6986 inhibits proliferation of MV4-11, MHH-CALL-4, MB002, MB004, and HD-MB03 cells (EC50s = 1.5, 0.4, 726, 336, and 3,583 nM, respectively) and reduces the viability of MV4-11 cells endogenously expressing cereblon but not MV4-11 cereblon knockout cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nishiguchi, G., Keramatnia, F., Min, J., et al. Identification of potent, selective, and orally bioavailable small-molecule GSPT1/2 degraders from a focused library of cereblon modulators. J. Med. Chem. 64(11), 7296-7311 (2021).