A matrix substance for MALDI-MS
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3-Hydroxypicolinic Acid

Item No. 34530

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-hydroxy-2-pyridinecarboxylic acid
CAS Number
874-24-8
Synonyms
  • 3-HPA
  • HPicOH
Molecular Formula
C6H5NO3
Formula Weight
139.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
304 nm
SMILES
O=C(C1=C(O)C=CC=N1)O
InChi Code
InChI=1S/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10)
InChi Key
BRARRAHGNDUELT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

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    Cayman Chemical
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    Product Description

    3-Hydroxypicolinic acid is a matrix substance in matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS) applications that has been used in the analysis of oligonucleotides and proteins.1,2 It has also been used as a complexation agent for metal complexes.3 3-Hydroxypicolinic acid is an intermediate in the biosynthesis of the antibiotic virginiamycin S1.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nordhoff, E., Kirpekar, F., Karas, M., et al. Comparison of IR- and UV-matrix-assisted laser desorption/ionization mass spectrometry of oligodeoxynucleotides. Nucleic Acids Res. 22(13), 2460-2465 (1994).

    2. Karas, M., Bahr, U., Strupat, K., et al. Matrix dependence of metastable fragmentation of glycoproteins in MALDI TOF mass spectrometry. Anal. Chem. 67(3), 675-679 (1995).

    3. Kiss, E., Petrohán, K., Sanna, D., et al. Solution speciation and spectral studies on oxovanadium(IV) complexes of pyridinecarboxylic acids. Polyhedron 19(1), 55-61 (2000).

    4. Reed, J.W., Purvis, M.B., Kingston, D.G.I., et al. Biosynthesis of antibiotics of the virginiamycin family. 7. Stereo- and regiochemical studies on the formation of the 3-hydroxypicolinic acid and pipecolic acid units. The Journal of Organic Chemistry 54(5), 1161-1165 (1989).