An atypical antipsychotic
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Alternative(s)
45296Lumateperone
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Lumateperone (tosylate)

Item No. 34541

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl)butan-1-one 4-methylbenzenesulfonic acid
CAS Number
1187020-80-9
Synonyms
  • ITI-007
Molecular Formula
C24H28FN3O • C7H8O3S
Formula Weight
565.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:7): 0.12 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
229 nm
SMILES
O=S(O)(C1=CC=C(C=C1)C)=O.O=C(C2=CC=C(F)C=C2)CCCN3CC[C@@]4([H])[C@@](C5=CC=CC6=C5N4CCN6C)([H])C3
InChi Code
InChI=1S/C24H28FN3O.C7H8O3S/c1-26-14-15-28-21-11-13-27(16-20(21)19-4-2-5-22(26)24(19)28)12-3-6-23(29)17-7-9-18(25)10-8-17;1-6-2-4-7(5-3-6)11(8,9)10/h2,4-5,7-10,20-21H,3,6,11-16H2,1H3;2-5H,1H3,(H,8,9,10)/t20-,21-;/m0./s1
InChi Key
LHAPOGAFBLSJJQ-GUTACTQSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $63

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    10 mg

    $118

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    25 mg

    $242

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    Product Description

    Lumateperone is an atypical antipsychotic.1 It selectively binds to the serotonin (5-HT) receptor subtype 5-HT2A over 5-HT1A and 5-HT2C receptors (Kis = 0.54, 1,480, and 173 nM, respectively). Lumateperone also binds to dopamine D1, D2, and D4 receptors (Kis = 52, 32, and 108 nM, respectively), α1A- and α1B-adrenergic receptors (Kis = 73 and 31 nM, respectively), and the 5-HT transporter (SERT; Ki = 61 nM). It reduces head-twitch behavior induced by the 5-HT2A agonist quipazine in rats (ED50 = 0.12 mg/kg). Formulations containing lumateperone have been used in the treatment of schizophrenia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, P., Zhang, Q., Robichaud, A.J., et al. Discovery of a tetracyclic quinoxaline derivative as a potent and orally active multifunctional drug candidate for the treatment of neuropsychiatric and neurological disorders. J. Med. Chem. 57(6), 2670-2682 (2014).