A 5-HT1B receptor agonist
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Alternative(s)
40817CP 93,129
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CP 93,129 (hydrochloride)

Item No. 34548

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4-dihydro-3-(1,2,3,6-tetrahydro-4-pyridinyl)-5H-pyrrolo[3,2-b]pyridin-5-one, dihydrochloride
CAS Number
879089-64-2
Molecular Formula
C12H13N3O • 2HCl
Formula Weight
288.2
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 100 mMWater: 100 mM
SMILES
O=C1C=CC2=C(N1)C(C3=CCNCC3)=CN2.Cl.Cl
InChi Code
InChI=1S/C12H13N3O.2ClH/c16-11-2-1-10-12(15-11)9(7-14-10)8-3-5-13-6-4-8;;/h1-3,7,13-14H,4-6H2,(H,15,16);2*1H
InChi Key
FLVJHUZZKVJQNH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $128

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    10 mg

    $182

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    25 mg

    $409

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    Product Description

    CP 93,129 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1B.1 It selectively binds 5-HT1B over 5-HT1A, 5-HT1C, 5-HT1D, and 5-HT2 receptors (Kis = 0.0081, 1.5, 2.9, 1.1, and 7.2 µM, respectively). CP 93,129 (5.4 µM) inhibits potassium-induced GABA release from rat globus pallidus slices.2 It reverses akinesia in a rat model of Parkinson’s disease induced by reserpine (Item No. 16474) when administered intrapallidally at doses of 110 and 220 nmol/animal. CP 93,129 reduces food intake in rats when infused into the pons parabrachial nucleus or the paraventricular nucleus (PVN) of the hypothalamus (ED50s = 1 and 50 nmol/animal, respectively).3 It also reduces the frequency of pursuits, tail rattles, threats, and attack bites in a resident-intruder test in mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Koe, B.K., Nielsen, J.A., Macor, J.E., et al. Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253. Drug Dev. Res. 26(3), 241-250 (1992).

    2. Chadha, A., Sur, C., Atack, J., et al. The 5HT1B receptor agonist, CP-93129, inhibits [3H]-GABA release from rat globus pallidus slices and reverses akinesia following intrapallidal injection in the reserpine-treated rat. Br. J. Pharmacol. 130(8), 1927-1932 (2000).

    3. Lee, M.D., Aloyo, V.J., Fluharty, S.J., et al. Infusion of the serotonin1B (5-HT1B) agonist CP-93,129 into the parabrachial nucleus potently and selectively reduces food intake in rats. Psychopharmacology (Berl.) 136(3), 304-307 (1997).

    4. Bannai, M., Fish, E.W., Faccidomo, S., et al. Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice. Psychopharmacology (Berl.) 193(2), 295-304 (2007).