A TRPC3 and TRPC6 activator
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GSK1702934A

Item No. 34576

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-1-[1-[(5,6,7,8-tetrahydro-4H-cyclohepta[b]thien-2-yl)carbonyl]-4-piperidinyl]-2H-benzimidazol-2-one
CAS Number
924377-85-5
Molecular Formula
C22H25N3O2S
Formula Weight
395.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
SMILES
O=C(C1=CC2=C(CCCCC2)S1)N(CC3)CCC3N4C(NC5=CC=CC=C54)=O
InChi Code
InChI=1S/C22H25N3O2S/c26-21(20-14-15-6-2-1-3-9-19(15)28-20)24-12-10-16(11-13-24)25-18-8-5-4-7-17(18)23-22(25)27/h4-5,7-8,14,16H,1-3,6,9-13H2,(H,23,27)
InChi Key
AXWRAIIIBRLXBP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $77

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    10 mg

    $135

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    Product Description

    GSK1702934A is an activator of transient receptor potential canonical 3 (TRPC3) and TRPC6.1 It induces TRPC3- and TRPC6-dependent currents in whole-cell patch-clamp assays using HEK293 cells expressing the human channels (EC50s = 0.08 and 0.44 µM, respectively). GSK1702934A enhances contractility and induces arrhythmias in hearts isolated from TRPC3-overexpressing, but not wild-type, mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xu, X., Lozinskaya, I., Costell, M., et al. Characterization of small molecule TRPC3 and TRPC6 agonist and antagonists. Biophys. J. 104(2), 454A (2013).

    2. Doleschal, B., Primessnig, U., Wölkart, G., et al. TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1. Cardiovasc. Res. 106(1), 163-173 (2015).