A Gal-3 inhibitor
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GB1107

Item No. 34584

Product Insert (PDF)
Technical Information
Formal Name
3,4-dichlorophenyl 3-deoxy-1-thio-3-[4-(3,4,5-trifluorophenyl)-1H-1,2,3-triazol-1-yl]-α-D-galactopyranoside
CAS Number
1978336-61-6
Molecular Formula
C20H16Cl2F3N3O4S
Formula Weight
522.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O[C@@H]1[C@@]([H])(N2N=NC(C3=CC(F)=C(F)C(F)=C3)=C2)[C@H]([C@H](O[C@@H]1SC4=CC(Cl)=C(C=C4)Cl)CO)O
InChi Code
InChI=1S/C20H16Cl2F3N3O4S/c21-10-2-1-9(5-11(10)22)33-20-19(31)17(18(30)15(7-29)32-20)28-6-14(26-27-28)8-3-12(23)16(25)13(24)4-8/h1-6,15,17-20,29-31H,7H2/t15-,17+,18+,19-,20-/m1/s1
InChi Key
CSGJIUAIYDKFPC-DABHTEOTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $65

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    5 mg

    $179

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    10 mg

    $293

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    25 mg

    $649

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    Cayman Chemical
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    Product Description

    GB1107 is an inhibitor of galectin-3 (Gal-3; IC50 = 8 µM).1 It prevents increases in Gal-3 levels induced by glycyl-L-phenylalanine 2-naphthylamide (GPN) in JIMT-1 breast cancer cells (IC50 = 36 nM). GB1107 (25 µM) induces apoptosis, induces cell cycle arrest at the G1 phase, and decreases the levels of aggrecan, chemokine (C-C motif) ligand 3 (Ccl3), and matrix metalloproteinase-3 (Mmp-3) in primary rat cartilage end plate cells.2 In vivo, GB1107 (0.1 mg/kg per day) increases survival and decreases pulmonary fibrosis but also decreases body weight in a mouse model of pulmonary fibrosis induced by bleomycin (Item No. 13877).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stegmayr, J., Zetterberg, F., Carlsson, M.C., et al. Extracellular and intracellular small-molecule galectin-3 inhibitors. Sci. Rep. 9(1), 2186 (2019).

    2. Li, J., Han, N., Liu, Z., et al. Role of Galectin-3 in intervertebral disc degeneration: An experimental study. BMC Musculoskelet. Disord. 25(1), 249 (2024).

    3. Jia, W., Wang, Z., Gao, C., et al. Trajectory modeling of endothelial-to-mesenchymal transition reveals galectin-3 as a mediator in pulmonary fibrosis. Cell Death Dis. 12(4), 327 (2021).