A C-21 steroid with anticancer activity
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Caudatin

Item No. 34585

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,12β,14β,17α)-12-[[(2E)-3,4-dimethyl-1-oxo-2-pentenyl]oxy]-3,8,14,17-tetrahydroxy-pregn-5-en-20-one
CAS Number
38395-02-7
Molecular Formula
C28H42O7
Formula Weight
490.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:7): 0.12 mg/ml
λmax
220 nm
SMILES
C[C@@]12[C@@]([C@]3([C@]([C@@]4(C(C[C@H](CC4)O)=CC3)C)([H])C[C@H]1OC(/C=C(C)/C(C)C)=O)O)(CC[C@@]2(O)C(C)=O)O
InChi Code
InChI=1S/C28H42O7/c1-16(2)17(3)13-23(31)35-22-15-21-24(5)9-8-20(30)14-19(24)7-10-27(21,33)28(34)12-11-26(32,18(4)29)25(22,28)6/h7,13,16,20-22,30,32-34H,8-12,14-15H2,1-6H3/b17-13+/t20-,21+,22+,24-,25+,26+,27-,28+/m0/s1
InChi Key
VWLXIXALPNYWFH-UXGQNDOZSA-N
Origin
Plant/Cynanchum otophyllum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $81

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    1 mg

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    5 mg

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    10 mg

    $475

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    Cayman Chemical
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    Product Description

    Caudatin is a C-21 steroid that has been found in C. auriculatum and has anticancer activity.1,2 It is cytotoxic to SMMC-7721, MCF-7, and HeLa cells (IC50s = 24.95, 65.82, and 247.54 µM, respectively).1 Caudatin (50-300 µM) induces apoptosis in and inhibits mammosphere formation by MDA-MB-231 breast cancer cells, as well as decreases the number of cancer stem cells (CSCs) in the MDA-MB-231 cell population.2 In vivo, caudatin (10 mg/kg) reduces tumor volume in an MDA-MB-231 mouse xenograft model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Peng, Y.-r., Li, Y.-b., Liu, X.-d., et al. Antitumor activity of C-21 steroidal glycosides from Cynanchum auriculatum Royle ex Wight. Phytomedicine 15(11), 1016-1020 (2008).

    2. Zhen, X., Choi, H.S., Kim, J.-H., et al. Caudatin isolated from Cynanchum auriculatum inhibits breast cancer stem cell formation via a GR/YAP signaling. Biomolecules 10(6), 925 (2020).