A coumarin with diverse biological activities
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Byakangelicin

Item No. 34600

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9-[(2R)-2,3-dihydroxy-3-methylbutoxy]-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one
CAS Number
482-25-7
Molecular Formula
C17H18O7
Formula Weight
334.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.2 mg/mlEthanol: 1 mg/ml
λmax
223, 249, 270, 273, 314 nm
SMILES
CC(C)(O)[C@H](O)COC1=C(OC=C2)C2=C(OC)C(C=C3)=C1OC3=O
InChi Code
InChI=1S/C17H18O7/c1-17(2,20)11(18)8-23-16-14-10(6-7-22-14)13(21-3)9-4-5-12(19)24-15(9)16/h4-7,11,18,20H,8H2,1-3H3/t11-/m1/s1
InChi Key
PKRPFNXROFUNDE-LLVKDONJSA-N
Origin
Plant/Angelica dahurica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $63

    Add

    5 mg

    $242

    Add

    10 mg

    $423

    Add

    25 mg

    $902

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Byakangelicin is a coumarin that has been found in A. dahurica and has diverse biological activities.1,2 It inhibits the activity of aldose reductase (IC50 = 6.2 µM for the bovine lens enzyme) and reduces cataract formation in a rat model of galactosemia when administered at a dose of 50 mg/kg per day.1 Byakangelicin (30 µM) decreases LPS-induced production of prostaglandin E2 (PGE2; Item No. 14010) in isolated rat peritoneal macrophages.2 It reduces cartilage erosion and loss of proteoglycan in the inflamed joints in a mouse model of surgically induced osteoarthritis when administered at a dose of 10 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shin, K.H., Chung, M.S., and Cho, T.S. Effects of furanocoumarins from Angelica dahurica on aldose reductase and galactosemic cataract formation in rats. Arch. Pharm. Res. 17(5), 331-336 (1994).

    2. Ban, H.S., Lim, S.S., Suzuki, K., et al. Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production. Planta Med. 69(5), 408-412 (2003).

    3. Zhang, T., He, L., Yang, W., et al. Byakangelicin inhibits IL-1β-induced mouse chondrocyte inflammation in vitro and ameliorates murine osteoarthritis in vivo. Int. Immunopharmacol. 85, 106605 (2020).