An alkaloid with anti-inflammatory and antioxidant activities
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Tetrahydrocoptisine

Item No. 34603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6,7,12b,13-tetrahydro-4H-bis[1,3]benzodioxolo[5,6-a:4′,5′-g]quinolizine
CAS Number
4312-32-7
Synonyms
  • NSC 110382
  • NSC 404529
  • (R,S±)-Stylopine
Molecular Formula
C19H17NO4
Formula Weight
323.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 5 mg/mlDMF: 1 mg/ml
SMILES
C12=CC=C3C(CN4CCC5=CC6=C(C=C5C4C3)OCO6)=C1OCO2
InChi Code
InChI=1S/C19H17NO4/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14/h1-2,6-7,15H,3-5,8-10H2
InChi Key
UXYJCYXWJGAKQY-UHFFFAOYSA-N
Origin
Plant/Unidentified sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Tetrahydrocoptisine is an alkaloid that has been found in C. impatiens and has anti-inflammatory and antioxidant activities.1,2 It inhibits LPS-induced NF-κB activation and production of nitric oxide (NO), TNF-α, and IL-6 in isolated mouse peritoneal macrophages when used at concentrations ranging from 0.001 to 1 µg/ml.1 Tetrahydrocoptisine (10 and 30 mg/kg) inhibits xylene-induced ear edema in mice, and it decreases serum levels of TNF-α in a mouse model of LPS-induced septic shock. It reduces the severity of ethanol-induced gastric ulcers in mice when administered at doses of 10 or 20 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, W., Huang, H., Zhang, Y., et al. Anti-inflammatory effect of tetrahydrocoptisine from Corydalis impatiens is a function of possible inhibition of TNF-α, IL-6 and NO production in lipopolysaccharide-stimulated peritoneal macrophages through inhibiting NF-κB activation and MAPK pathway. Eur. J. Pharmacol. 715(1-3), 62-71 (2013).

    2. Li, W., Huang, H., Niu, X., et al. Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice. Toxicol. Appl. Pharmacol. 272(1), 21-29 (2013).