An anxiolytic with antiepileptic activity
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Mebicar

Item No. 34606

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
tetrahydro-1,3,4,6-tetramethyl-imidazo[4,5-d]imidazole-2,5(1H,3H)-dione
CAS Number
10095-06-4
Synonyms
  • Mebikar
Molecular Formula
C8H14N4O2
Formula Weight
198.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C1N(C2N(C)C(N(C2N1C)C)=O)C
InChi Code
InChI=1S/C8H14N4O2/c1-9-5-6(11(3)7(9)13)12(4)8(14)10(5)2/h5-6H,1-4H3
InChi Key
XIUUSFJTJXFNGH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 mg

    $49

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    50 mg

    $93

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    100 mg

    $171

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    250 mg

    $329

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    Product Description

    Mebicar is an anxiolytic with antiepileptic activity.1,2 In vivo, mebicar (10 mg/kg) reduces anxiety-like behavior and decreases stress-induced increases in serum corticosterone and pro-inflammatory cytokine levels in a mouse model of intermittent unpredictable stress.1 It inhibits epileptic activity in a rat model of penicillin-induced focal epilepsy.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, C.Y., Kim, Y.G., Sin, S.J., et al. Preventive effect of mebicar and ginsenoside Rg1 on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in mice. NeuroImmunoModulation 25(1), 49-58 (2018).

    2. Rekhtman, M.B., Torshin, V.I., and Darinskiĭ, N.V. Effect of mebikar on focal epileptic activity. Biull. Eksp. Biol. Med. 91(2), 178-181 (1981).