An anticancer agent
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7-ethyl Camptothecin

Item No. 34607

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS Number
78287-27-1
Synonyms
  • SN-22
Molecular Formula
C22H20N2O4
Formula Weight
376.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/ml
λmax
220, 254, 359 nm
SMILES
O=C1N2C(C3=NC4=CC=CC=C4C(CC)=C3C2)=CC5=C1COC([C@]5(O)CC)=O
InChi Code
InChI=1S/C22H20N2O4/c1-3-12-13-7-5-6-8-17(13)23-19-14(12)10-24-18(19)9-16-15(20(24)25)11-28-21(26)22(16,27)4-2/h5-9,27H,3-4,10-11H2,1-2H3/t22-/m0/s1
InChi Key
MYQKIWCVEPUPIL-QFIPXVFZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    7-ethyl Camptothecin is a derivative of camptothecin (Item No. 11694) and an anticancer agent.1,2 It inhibits wild-type but not Gly533 mutant topoisomerase I in RPMI-8402 and CPT-K5 cells, respectively (IC50s = 5.48 and >2,500 nM, respectively).1 7-ethyl Camptothecin is cytotoxic to ADJ/PC6 SN-38-sensitive and PC6/SN2-5H2 SN-38-resistant cells (IC50s = 0.85 and 2.98 nM, respectively). In vivo, 7-ethyl camptothecin (0.25-3 mg/kg per day) increases survival in Ehrlich, MM46, Meth A, L1210, P388, and B16/F10 mouse ascites tumor models.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoshikawa, M., Ikegami, Y., Hayasaka, S., et al. Novel camptothecin analogues that circumvent ABCG2-associated drug resistance in human tumor cells. Int. J. Cancer 110(6), 921-927 (2004).

    2. Kunimoto, T., Nitta, K., Tanaka, T., et al. Antitumor activity of a new camptothecin derivative, SN-22, against various murine tumors. J. Pharmacobiodyn. 10(3), 148-151 (1987).