A biflavone with diverse biological activities
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Isomer(s)
27899Bilobetin
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Podocarpusflavone A

Item No. 34613

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
22136-74-9
Synonyms
  • PCFA
Molecular Formula
C31H20O10
Formula Weight
552.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: soluble
λmax
272, 334 nm
SMILES
O=C1C=C(C2=CC(C3=C(C=C(C4=C3OC(C5=CC=C(OC)C=C5)=CC4=O)O)O)=C(O)C=C2)OC6=C1C(O)=CC(O)=C6
InChi Code
InChI=1S/C31H20O10/c1-39-17-5-2-14(3-6-17)25-13-24(38)30-22(36)11-21(35)28(31(30)41-25)18-8-15(4-7-19(18)33)26-12-23(37)29-20(34)9-16(32)10-27(29)40-26/h2-13,32-36H,1H3
InChi Key
RBTRUVNXLDXHBJ-UHFFFAOYSA-N
Origin
Plant/Selaginella
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    Podocarpusflavone A is a biflavone that has been found in D. araucarioides and has diverse biological activities.1,2,3,4 It inhibits dengue virus NS5 RNA-dependent RNA polymerase (DENV-NS5 RdRp; IC50 = 0.75 µM).3 Podocarpusflavone A also inhibits cathepsin B with an IC50 value of 1.68 µM and inhibits STAT3 in a reporter assay in a concentration-dependent manner.1,2 It reduces the production of reactive oxygen species (ROS) and superoxide anions induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in isolated human neutrophils when used at concentrations of 1 and 10 µM, respectively.4 Podocarpusflavone A also inhibits aggregation of amyloid-β (1-40) peptide (Aβ40; Item No. 21617) in a cell-free assay with an IC50 value of 4.9 μM.5 Podocarpusflavone A (20 µM) decreases viability of A375, MALME-3M, SK-MEL-1, and SK-MEL-5 melanoma cells and reduces tumor growth in an A375 mouse xenograft model when administered at doses of 20 and 40 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, Y., Tan, N.S., Huang, H., et al. Three bioactive biflavones isolated from Taxodium mucronatum. Yunnan Zhiwu Yanjiu 27(1), 107-110 (2005).

    2. Meng, H., Pang, Y., Liu, G., et al. Podocarpusflavone A inhibits cell growth of skin cutaneous melanoma by suppressing STAT3 signaling. J. Dermatol. Sci. 100(3), 201-208 (2020).

    3. Coulerie, P., Nour, M., Maciuk, A., et al. Structure-activity relationship study of biflavonoids on the Dengue virus polymerase DENV-NS5 RdRp. Planta Med. 79(14), 1313-1318 (2013).

    4. Arwa, P.S., Zeraik, M.L., Ximenes, V.F., et al. Redox-active biflavonoids from Garcinia brasiliensis as inhibitors of neutrophil oxidative burst and human erythrocyte membrane damage. J. Ethnopharmacol. 174, 410-418 (2015).

    5. Sirimangkalakitti, N., Juliawaty, L.D., Hakim, E.H., et al. Naturally occurring biflavonoids with amyloid β aggregation inhibitory activity for development of anti-Alzheimer agent. Bioorg. Med. Chem. Lett. 29(15), 1994-1997 (2019).