A flavonoid with diverse biological activities
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Corylifol A

Item No. 34616

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-4-hydroxyphenyl]-7-hydroxy-4H-1-benzopyran-4-one
CAS Number
775351-88-7
Synonyms
  • Corylinin
Molecular Formula
C25H26O4
Formula Weight
390.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.30 mg/mlEthanol: 25 mg/ml
λmax
249 nm
SMILES
O=C1C(C2=CC(C/C=C(C)/CC/C=C(C)\C)=C(C=C2)O)=COC3=CC(O)=CC=C31
InChi Code
InChI=1S/C25H26O4/c1-16(2)5-4-6-17(3)7-8-19-13-18(9-12-23(19)27)22-15-29-24-14-20(26)10-11-21(24)25(22)28/h5,7,9-15,26-27H,4,6,8H2,1-3H3/b17-7+
InChi Key
ZBHUUXLHDOUMKM-REZTVBANSA-N
Origin
Plant/Psoralea corylifolia
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    Corylifol A is a flavonoid that has been found in P. corylifolia and has diverse biological activities.1,2,3,4 It inhibits the activity of carboxylesterase 2 (CES2; Ki = 0.62 µM for the human enzyme), as well as induces estrogen receptor α (ERα) and ERβ transcriptional activation in reporter assays using HeLa cells when used at concentrations ranging from 0.1 to 10 µM.2,3 Corylifol A is cytotoxic to (IC50 = 13.5 µg/ml), and inhibits IL-6-induced STAT3 promoter activity in (IC50 = 0.81 µM in a reporter assay), Hep3B hepatocellular carcinoma cells.4,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lee, S.W., Yun, B.R., Kim, M.H., et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation. Planta Med. 78(9), 903-906 (2012).

    2. Li, Y.-G., Hou, J., Li, S.-Y., et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2. Fitoterapia 101, 99-106 (2015).

    3. Xin, D., Wang, H., Yang, J., et al. Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity. Phytomedicine 17(2), 126-131 (2010).

    4. Song, P., Yang, X.-Z., and Yuan, J.-Q. Cytotoxic constituents from Psoralea corylifolia. J. Asian Nat. Prod. Res. 15(6), 624-630 (2013).