A steroidal alkaloid with diverse biological activities
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Veratrosine

Item No. 34617

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,23β)-14,15,16,17-tetradehydro-23-hydroxyveratraman-3-yl, β-D-glucopyranoside
CAS Number
475-00-3
Synonyms
  • Veratramine 3-O-glucoside
Molecular Formula
C33H49NO7
Formula Weight
571.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)([H])C5=CC=C([C@@H]([C@@]6([H])[C@@H](C[C@@H](CN6)C)O)C)C(C)=C5C3
InChi Code
InChI=1S/C33H49NO7/c1-16-11-26(36)28(34-14-16)18(3)21-7-8-22-23-6-5-19-12-20(9-10-33(19,4)25(23)13-24(22)17(21)2)40-32-31(39)30(38)29(37)27(15-35)41-32/h5,7-8,16,18,20,23,25-32,34-39H,6,9-15H2,1-4H3/t16-,18-,20-,23-,25-,26+,27+,28-,29+,30-,31+,32+,33-/m0/s1
InChi Key
WXQHVBNTINGJJR-NIFRNHPISA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $175

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    5 mg

    $481

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    10 mg

    $788

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    Product Description

    Veratrosine is a steroidal alkaloid that has been found in Veratrum and has diverse biological activities.1,2 It inhibits hedgehog (Hh) signaling in a reporter assay using NIH3T3 cells when used at a concentration of 8 µM.1 Veratrosine (1 mg/ml) inhibits aggregation of isolated rabbit platelets induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607). It induces DNA damage in the cerebellum and cerebral cortex in mice when administered at doses of 0.25 and 2.5 µmol/kg.2 Veratrosine (1.5 and 4.5 µmol/kg) decreases angiotensin II-induced increases in systolic blood pressure in mice.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tang, J., Li, H.L., Shen, Y.H., et al. Antitumor and antiplatelet activity of alkaloids from Veratrum dahuricum. Phytother. Res. 24(6), 821-826 (2010).

    2. Cong, Y., Wu, Y., Shen, S., et al. A structure-activity relationship between the Veratrum alkaloids on the antihypertension and DNA damage activity in mice. Chem. Biodivers. 17(2), e1900473 (2020).