A uPA and factor Xa inhibitor
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GGACK (hydrochloride)

Item No. 34618

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(2-chloroacetyl)butyl]-glycinamide, monohydrochloride
Synonyms
  • Glu-Gly-Arg-Chloromethyl Ketone
  • Glu-Gly-Arg-CH2Cl
Molecular Formula
C14H25ClN6O5 • HCl
Formula Weight
429.3
Purity
≥95%
Formulation
A 10 mg/ml solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(CCl)[C@H](CCCNC(N)=N)NC(CNC([C@@H](N)CCC(O)=O)=O)=O.Cl
InChi Code
InChI=1S/C14H25ClN6O5.ClH/c15-6-10(22)9(2-1-5-19-14(17)18)21-11(23)7-20-13(26)8(16)3-4-12(24)25;/h8-9H,1-7,16H2,(H,20,26)(H,21,23)(H,24,25)(H4,17,18,19);1H/t8-,9-;/m0./s1
InChi Key
NEQXMWUJEBHDHT-OZZZDHQUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

    Add

    5 mg

    $303

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    10 mg

    $553

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    Product Description

    GGACK is an inhibitor of urokinase-type plasminogen activator (uPA) and factor Xa (Kis = 1.8 and 8.7 µM, respectively).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kettner, C., and Shaw, E. The susceptibility of urokinase to affinity labeling by peptides of arginine chloromethyl ketone. Biochim. Biophys. Acta 569(1), 31-40 (1979).

    2. Kettner, C., and Shaw, E. The selective affinity labeling of factor Xa by peptides of arginine chloromethyl ketone. Thromb. Res. 22(5-6), 645-652 (1981).