A TNAP inhibitor
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SBI-425

Item No. 34626

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[(5-chloro-2-methoxyphenyl)sulfonyl]amino]-3-pyridinecarboxamide
CAS Number
1451272-71-1
Molecular Formula
C13H12ClN3O4S
Formula Weight
341.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
O=C(C1=CC(NS(=O)(C2=CC(Cl)=CC=C2OC)=O)=CN=C1)N
InChi Code
InChI=1S/C13H12ClN3O4S/c1-21-11-3-2-9(14)5-12(11)22(19,20)17-10-4-8(13(15)18)6-16-7-10/h2-7,17H,1H3,(H2,15,18)
InChi Key
SBAITEDLNTYIOE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $37

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    5 mg

    $99

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    10 mg

    $181

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    25 mg

    $404

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    Product Description

    SBI-425 is an inhibitor of tissue-nonspecific alkaline phosphatase (TNAP; IC50 = 0.016 µM).1 It is selective for TNAP over a panel of 35 targets at 10 µM. SB-425 (10 and 30 mg/kg) increases survival and nearly completely inhibits the development of medial arterial calcification in a mouse model of chronic kidney disease-mineral bone disorder (CKD-MBD) induced by a high-adenine high-phosphate diet.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pinkerton, A.B., Sergienko, E., Bravo, Y., et al. Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor. Bioorg. Med. Chem. Lett. 28(1), 31-34 (2018).

    2. Tani, T., Fujiwara, M., Orimo, H., et al. Inhibition of tissue-nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD-MBD mouse model. J. Pathol. 250(1), 30-41 (2020).