Active • Host: HEK293 cells • AA: 33-320 • Tag: C-terminal IgG1 Fc-AVI • MW: 62 kDa
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Interleukin-17RA/CD217 Extracellular Domain (human, recombinant)

Item No. 34632

Product Insert (PDF)
Technical Information
Synonyms
  • CDw217
  • IL-17 Receptor A
  • Interleukin-17 Receptor A
Purity
≥80% estimated by SDS-PAGE
Source
Active recombinant C-terminal human IgG1 Fc-AVI-tagged IL-17RA expressed in HEK293 cells
Amino Acids
33-320
MW
62 kDa
Formulation (Request formulation change)
8 mM phosphate buffer, pH 7.4, with 110 mM sodium chloride, 2.2 mM potassium chloride, and 20% glycerol
UniProt Accession №
Q96F46
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $388

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    Cayman Chemical
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    Product Description

    IL-17 receptor A (IL-17RA), also known as CD217, is a cytokine receptor that has roles in immunity and inflammation.1 It is composed of two extracellular fibronectin III-like domains that form the ligand-binding and receptor-dimerization domain, a transmembrane domain, an SEF/IL-17R (SEFIR) domain, a TIR-like loop (TILL), and a C/EBPβ activation domain (CBAD). IL-17RA is ubiquitously expressed and localizes to the plasma membrane.2 It also exists as a soluble form that results from alternative splicing of IL17RA pre-mRNA. IL-17RA is involved in autoimmunity, neutrophil recruitment, and host defense.1 It forms a complex with IL-17RB, IL-17RC, or IL-17RE, each of which have varying affinities for the homodimeric ligands IL-17A, IL-17E, and IL-17F, and the IL-17A/IL-17F heterodimer.1,3 Knockout of Il17ra increases mortality in mice infected with T. cruzi.4 In contrast, Il17ra-/- mice are protected against the development of collagen-induced arthritis.5 Mutations in IL17RA have been found in patients with chronic mucocutaneous candidiasis, a disease characterized by recurrent or persistent commensal Candida infections.6 Cayman's Interleukin-17RA/CD217 Extracellular Domain (human, recombinant) protein can be used for binding assays. This protein is a disulfide-linked homodimer. The reduced monomer, composed of IL-17RA fused to AVI-tagged IgG1 Fc at its C-terminus, has a calculated molecular weight of 62 kDa. As a result of glycosylation, the monomer migrates at approximately 95 kDa by SDS-PAGE under reducing conditions.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gaffen, S.L. Structure and signalling in the IL-17 receptor family. Nat. Rev. Immunol. 9(8), 556-567 (2009).

    2. Sohda, M., Misumi, Y., Tashiro, K., et al. Identification of a soluble isoform of human IL-17RA generated by alternative splicing. Cytokine 64(3), 642-645 (2013).

    3. Vidal, S., Puig, L., Carrascosa-Carrillo, J.-M., et al. From messengers to receptors in psoriasis: The role of IL-17RA in disease and treatment. Int. J. Mol. Sci. 22(13), 6740 (2021).

    4. Tosello Boari , J., Amezcua Vesely, M.C., Bermejo, D.A., et al. IL-17RA signaling reduces inflammation and mortality during Trypanosoma cruzi infection by recruiting suppressive IL-10-producing neutrophils. PLoS Pathog. 8(4), e1002658 (2012).

    5. Corneth, O.B.J., Mus, A.M.C., Asmawidjaja, P.S., et al. Absence of interleukin-17 receptor a signaling prevents autoimmune inflammation of the joint and leads to a Th2-like phenotype in collagen-induced arthritis. Arthritis Rheumatol. 66(2), 340-349 (2014).

    6. Lévy, R., Okada, S., Béziat, V., et al. Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency. Proc. Natl. Acad. Sci. USA 113(51), E8277-E8285 (2016).