An acetylated form of L-aspartic acid
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N-Acetyl-DL-Aspartic Acid

Item No. 34635

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-acetyl-aspartic acid
CAS Number
2545-40-6
Synonyms
  • NSC 128611
Molecular Formula
C6H9NO5
Formula Weight
175.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC(CC(NC(C)=O)C(O)=O)=O
InChi Code
InChI=1S/C6H9NO5/c1-3(8)7-4(6(11)12)2-5(9)10/h4H,2H2,1H3,(H,7,8)(H,9,10)(H,11,12)
InChi Key
OTCCIMWXFLJLIA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $134

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    10 g

    $240

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    25 g

    $466

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    50 g

    $795

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    Product Description

    N-Acetyl-DL-aspartic acid is an acetylated form of L-aspartic acid.1 It is formed from L-aspartate and acetyl-CoA (Item No. 16160) by L-aspartate N-acetyltransferase (Asp-NAT) in neuronal mitochondria.2 N-Acetyl-DL-aspartic acid is hydrolyzed to L-aspartate and acetate by aspartoacylase (ASPA), which is expressed by oligodendrocytes. N-Acetyl-DL-aspartic acid levels are increased in the brain of patients with Canavan disease, an autosomal recessive disorder caused by loss-of-function ASPA mutations and characterized by cognitive and motor impairments.3,2,1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baslow, M.H. A review of phylogenetic and metabolic relationships between the acylamino acids, N-acetyl-ʟ-aspartic acid and N-acetyl-ʟ-histidine, in the vertebrate nervous system. J. Neurochem. 68(4), 1335-1344 (1997).

    2. Madhavarao, C.N., Arun, P., Moffett, J.R., et al. Defective N-acetylaspartate catabolism reduces brain acetate levels and myelin lipid synthesis in Canavan’s disease. Proc. Natl. Acad. Sci. USA 102(14), 5221-5226 (2004).

    3. Bannerman, P., Guo, F., Chechneva, O., et al. Brain Nat8l knockdown suppresses spongiform leukodystrophy in an aspartoacylase-deficient Canavan disease mouse model. Mol. Ther. 26(3), 793-800 (2018).