A phospholipid metabolite
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O-Phosphoethanolamine

Item No. 34636

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-ethanol, 1-(dihydrogen phosphate)
CAS Number
1071-23-4
Synonyms
  • O-Phosphorylethanolamine
  • NSC 254167
Molecular Formula
C2H8NO4P
Formula Weight
141.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=P(O)(OCCN)O
InChi Code
InChI=1S/C2H8NO4P/c3-1-2-7-8(4,5)6/h1-3H2,(H2,4,5,6)
InChi Key
SUHOOTKUPISOBE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    O-Phosphoethanolamine is an endogenous phospholipid metabolite.1 It is also a precursor in the biosynthesis of phosphatidylethanolamines in the endoplasmic reticulum. O-Phosphoethanolamine is also incorporated into lipid A, a component of LPS.2 It decreases disease severity in a mouse model of cerulein-induced acute pancreatitis.3 Levels of O-phosphoethanolamine are decreased in postmortem amygdala from patients with Parkinson’s disease.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Podo, F. Tumour phospholipid metabolism. NMR Biomed. 12(7), 413-349 (1999).

    2. Samantha, A., and Vrielink, A. Lipid A phosphoethanolamine transferase: Regulation, structure and immune response. J. Mol. Biol. 432(18), 5184-5196 (2020).

    3. Sakai, A., Nishiumi, S., Shiomi, Y., et al. Metabolomic analysis to discover candidate therapeutic agents against acute pancreatitis. Arch. Biochem. Biophys. 522(2), 107-120 (2012).

    4. Kish, S.J., Rajput, A., Gilbert, J., et al. Elevated y-aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson’s disease: Correlation with striatal dopamine loss. Ann. Neurol. 20(1), 26-31 (1986).