Skimmianine

Skimmianine is a furoquinoline alkaloid that has been found in Z. nitidum and has diverse biological activities.^1,2,3,4 It inhibits acetylcholinesterase (AChE; IC₅₀ = 8.6 µg/ml for the human enzyme).¹ Skimmianine is active against P. falciparum (IC₅₀ = 48.2 µg/ml), as well as L. gongylophorus, a symbiotic fungus of the agricultural pest A. sexdens (leaf-cutting ant).^2,3 It reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice (ED₄₅ = 0.75 mg/ear).⁴

WARNING This product is not for human or veterinary use.

1. Yang, Z.-d., Zhang, D.-b., Ren, J., et al. Skimmianine, a furoquinoline alkaloid from Zanthoxylum nitidum as a potential acetylcholinesterase inhibitor. Med. Chem. Res. 21, 722-725 (2011).

2. Khalid, S.A., Farouk, A., Geary, T.G., et al. Potential antimalarial candidates from African plants: And in vitro approach using Plasmodium falciparum. J. Ethnopharmacol. 15(2), 201-209 (1986).

3. Biavatti, M.W., Vieira, P.C., da Silva, F.d.G.F., et al. Biological activity of quinoline alkaloids from Raulinoa echinata and x-ray structure of flindersiamine. J. Braz. Chem. Soc. 13(1), 66-70 (2002).

4. García-Argáez, A.N., Ramírez Apan, T.O., Parra Delgado, H., et al. Anti-inflammatory activity of coumarins from Decatropis bicolor on TPA ear mice model. Planta Med. 66(3), 279-281 (2000).