Dictamnine

Dictamnine is an alkaloid that has been found in D. dasycarpus and has diverse biological activities.^1,2,3 It inhibits platelet aggregation induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), collagen, thrombin, or platelet-activating factor (PAF) in washed isolated rabbit platelets when used at a concentration of 100 µg/ml.² Dictamnine is cytotoxic to human KB oral, HeLa cervical, and DLD-1 colon cancer cells (EC₅₀s = 20.55, 2.5, and 6.4 µg/ml, respectively) and induces apoptosis in A549, PC-9, and EBC-1 human lung cancer cells when used at concentrations ranging from 50 to 200 µM.^2,1 It increases serum alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities and induces hepatocyte necrosis in mice when administered at doses of 150 or 200 mg/kg.³

WARNING This product is not for human or veterinary use.

1. Yu, J., Zhang, L., Peng, J., et al. Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways. Biochem. Pharmacol. 195, 114864 (2022).

2. Wu, T.-S., Shi, L.-S., Wang, J.-J., et al. Cytotoxic and antiplatelet aggregation principles of Ruta graveolens. J. Chin. Chem. Soc. 50(1), 171-178 (2003).

3. Lin, Q., Guan, H., Ma, C., et al. Biotransformation patterns of dictamnine in vitro/in vivo and its relative molecular mechanism of dictamnine-induced acute liver injury in mice. Environ. Toxicol. Pharmacol. 85, 103628 (2021).