A triterpene with anti-inflammatory activity
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Isomer(s)
373643-keto Ursolic Acid
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Wilforlide A

Item No. 34654

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,20α,22α)-3,22-dihydroxy-olean-12-en-29-oic acid, γ-lactone
CAS Number
84104-71-2
Synonyms
  • (–)-Abruslactone
  • Abruslactone A
  • Regelide
Molecular Formula
C30H46O3
Formula Weight
454.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: 10 mg/ml
SMILES
C[C@@]12C([C@@]3([H])[C@@](CC2)([C@@H]4C[C@](C3)(C(O4)=O)C)C)=CC[C@@]5([H])[C@]1(CC[C@]6([H])[C@@]5(CC[C@@H](C6(C)C)O)C)C
InChi Code
InChI=1S/C30H46O3/c1-25(2)20-10-13-30(7)21(28(20,5)12-11-22(25)31)9-8-18-19-16-26(3)17-23(33-24(26)32)27(19,4)14-15-29(18,30)6/h8,19-23,31H,9-17H2,1-7H3/t19-,20-,21+,22-,23-,26-,27+,28-,29+,30+/m0/s1
InChi Key
HHQJBWYXBWOFJY-YLXTXNMFSA-N
Origin
Plant/Tripterygium wilfordii
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $168

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    25 mg

    $347

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    50 mg

    $510

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    Product Description

    Wilforlide A is a triterpene that has been found in T. wilfordii and has anti-inflammatory activity.1,2 It inhibits xylene-induced ear swelling in mice when administered at doses of 60 or 300 µg/kg.1 Wilforlide A in combination with triptolide reduces inflammation, bone damage, and synovial hyperplasia in the inflamed joints in a rat model of collagen-induced arthritis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Xue, M., Jiang, Z.-Z., Liu, J.-P., et al. Comparative study on the anti-inflammatory and immune suppressive effect of Wilforlide A. Fitoterapia 81(8), 1109-1112 (2010).

    2. Zhu, X., Zhang, J., Huo, R., et al. Evaluation of the efficacy and safety of different Tripterygium preparations on collagen-induced arthritis in rats. J. Ethnopharmacol. 158(Pt A), 283-290 (2014).