Fraxinellone

Fraxinellone is a liminoid degradant that has been found in D. dasycarpus and has diverse biological activities.^1,2,3 It has antifeedant activity against, and inhibits development of, armyworm (M. separata) larvae when applied to fresh wheat leaves at concentrations of 5, 10, or 20 mg/ml.¹ Fraxinellone (6.25, 12.5, and 25 µM) reduces LPS-induced nuclear translocation of the NF-κB subunit p65, as well as inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E₂ (PGE₂; Item No. 14010) in RAW 264.7 cells.² It reduces tumor growth in an A549 mouse xenograft model when administered at doses of 30 or 100 mg/kg.³

WARNING This product is not for human or veterinary use.

1. Lü, M., Wu, W., and Liu, H. Insecticidal and feeding deterrent effects of fraxinellone from Dictamnus dasycarpus against four major pests. Molecules 18(3), 2754-2762 (2013).

2. Kim, J.-H., Park, Y.-M., Shin, J.-S., et al. Fraxinellone inhibits lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by negatively regulating nuclear factor-kappa B in RAW 264.7 macrophages cells. Biol. Pharm. Bull. 32(6), 1062-1068 (2009).

3. Xing, Y., Mi, C., Wang, Z., et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol. Res. 135, 166-180 (2018).