A diterpene alkaloid with analgesic activity
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Crassicauline A

Item No. 34674

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,6α,14α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-8,13,14-triol, 8-acetate 14-(4-methoxybenzoate)
CAS Number
79592-91-9
Synonyms
  • 3-Deoxyyunaconitine
Molecular Formula
C35H49NO10
Formula Weight
643.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:8): 0.11 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
258 nm
SMILES
CO[C@@H](CC1)C([C@@](C[C@@]23O)([H])[C@H](C2([H])OC(C(C=C4)=CC=C4OC)=O)[C@@]5(C[C@@H]3OC)OC(C)=O)(C(N6CC)C5[C@@H]7OC)[C@@]7([H])[C@@]1(C6)COC
InChi Code
InChI=1S/C35H49NO10/c1-8-36-17-32(18-40-3)14-13-23(42-5)35-22-15-33(39)24(43-6)16-34(46-19(2)37,26(29(35)36)27(44-7)28(32)35)25(22)30(33)45-31(38)20-9-11-21(41-4)12-10-20/h9-12,22-30,39H,8,13-18H2,1-7H3/t22-,23+,24+,25-,26?,27+,28-,29?,30?,32+,33+,34-,35?/m1/s1
InChi Key
GAZDXIGXYWVWQX-MIOGPJTISA-N
Origin
Plant/Aconitum transsectum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $103

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    25 mg

    $244

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    50 mg

    $432

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    Product Description

    Crassicauline A is a diterpene alkaloid originally isolated from A. crassicaule that has analgesic activity.1,2 It inhibits acetic acid-induced writhing in mice (ED50 = 0.048 mg/kg) and induces lethality in mice when administered at doses greater than 0.92 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fengpeng, W., and Qicheng, F. Alkaloids from roots of Aconitum crassicaule. Planta Med. 42(8), 375-379 (1981).

    2. Wang, J.-L., Shen, X.-L., Chen, Q.-H., et al. Structure–analgesic activity relationship studies on the C18- and C19-diterpenoid alkaloids. Chem. Pharmaceut. Bull. 57(8), 801-807 (2009).