An internal standard for the quantification of spermidine
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Unlabeled Version(s)
14918Spermidine
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Spermidine-d6

Item No. 34697

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N1-(3-aminopropyl-1,1,2,2,3,3-d6)butane-1,4-diamine
CAS Number
2514812-10-1
Molecular Formula
C7H13D6N3
Formula Weight
151.3
Purity
≥99% deuterated forms (d1-d6)
Formulation
A 10 mg/ml solution in water
Solubility(Learn about Variance in Solubility)
Water: 50 mg/ml
SMILES
NCCCCNC([2H])(C([2H])(C([2H])(N)[2H])[2H])[2H]
InChi Code
InChI=1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2/i3D2,5D2,7D2
InChi Key
ATHGHQPFGPMSJY-RCKJUGKUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $267

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    5 mg

    $997

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    Product Description

    Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine (Item No. 14918) by GC- or LC-MS. Spermidine is an endogenous polyamine.1 It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay.1 It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans.2 Spermidine (30 mM in the drinking water) reduces demyelination of the optic nerve and disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).3 It reduces increases in blood pressure, left ventricular posterior wall thickness, and heart weight in salt-sensitive Dahl rats fed a high-salt diet, a model of hypertension-induced congestive heart failure.4 Formulations containing spermidine have been used as dietary supplements.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Madeo, F., Eisenberg, T., Pietrocola, F., et al. Spermidine in health and disease. Science 359(6374), eaan2788 (2018).

    2. Eisenberg, T., Knauer, H., Schauer, A., et al. Induction of autophagy by spermidine promotes longevity. Nat. Cell Biol. 11(11), 1305-1314 (2009).

    3. Guo, X., Harada, C., Namekata, K., et al. Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis. Invest. Ophthalmol. Vis. Sci. 52(5), 2696-2703 (2011).

    4. Eisenberg, T., Abdellatif, M., Schroeder, S., et al. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat. Med. 22(12), 1428-1438 (2016).